The Omega-3 Fatty Acid Docosahexaenoic Acid Attenuates Organic Dust-Induced Airway Inflammation
| العنوان: | The Omega-3 Fatty Acid Docosahexaenoic Acid Attenuates Organic Dust-Induced Airway Inflammation |
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| المؤلفون: | Taylor D. Friemel, Debra J. Romberger, Todd A. Wyatt, Tara M. Nordgren, Art J. Heires, Jill A. Poole |
| المصدر: | Nutrients, Vol 6, Iss 12, Pp 5434-5452 (2014) Nutrients Volume 6 Issue 12 Pages 5434-5452 |
| بيانات النشر: | MDPI AG, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Chemokine, Swine, medicine.medical_treatment, Anti-Inflammatory Agents, airway inflammation, Monocytes, Lung, specialized pro-resolving mediators (SPM), 2. Zero hunger, Inhalation exposure, chemistry.chemical_classification, Air Pollutants, Inhalation Exposure, Nutrition and Dietetics, biology, food and beverages, Dust, respiratory system, Intercellular Adhesion Molecule-1, 3. Good health, medicine.anatomical_structure, Cytokine, Neutrophil Infiltration, Docosahexaenoic acid, Inflammation Mediators, lcsh:Nutrition. Foods and food supply, Docosahexaenoic Acids, lcsh:TX341-641, Article, Cell Line, medicine, Animals, Humans, docosahexaenoic acid (DHA), Omega 3 fatty acid, Dose-Response Relationship, Drug, Monocyte, Fatty acid, Epithelial Cells, Pneumonia, Fibroblasts, organic dust, respiratory tract diseases, Mice, Inbred C57BL, Disease Models, Animal, chemistry, Immunology, biology.protein, Food Science |
| الوصف: | Workers exposed to organic dusts from concentrated animal feeding operations (CAFOs) are at risk for developing airway inflammatory diseases. Available preventative and therapeutic measures for alleviating dust-induced lung disease are inadequate. Because omega-3 fatty acids can mitigate inflammatory processes, we aimed to determine whether nutritional supplementation with the omega-3 fatty acid docosahexaenoic acid (DHA) could reduce the airway inflammatory consequences of exposures to organic dust. Aqueous extracts of organic dusts from swine CAFOs (ODE) were utilized. In DHA-pretreated human bronchial epithelial cells, lung fibroblasts, monocyte cell cultures, and precision-cut murine lung slices, we found that DHA pretreatment dose-dependently decreased ODE-induced inflammatory cytokine production. To determine the in vivo significance of DHA, C57BL/6 mice were orally administered DHA for seven days prior to treatment with intranasal ODE or saline inhalations. Animals treated with 2 mg DHA demonstrated significant reductions in ODE-induced bronchial alveolar lavage neutrophil influx and pro-inflammatory cytokine/chemokine production compared to mice exposed to ODE alone. Collectively, these data demonstrate that DHA affects several lung cells to reduce the airway inflammatory response to organic dust exposures. Dietary supplementation with DHA may be an effective therapeutic strategy to reduce the airway inflammatory consequences in individuals exposed to agriculture dust environments. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06175bc0829263fbb341876fa3492fbbTest http://www.mdpi.com/2072-6643/6/12/5434Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....06175bc0829263fbb341876fa3492fbb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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