At the X-Roads of Sex and Genetics in Pulmonary Arterial Hypertension
| العنوان: | At the X-Roads of Sex and Genetics in Pulmonary Arterial Hypertension |
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| المؤلفون: | Samuel M. Brown, Greg Elliott, Tim Lahm, Meghan M. Cirulis, Lynn M. Brown, Mark W. Dodson |
| المصدر: | Genes, Vol 11, Iss 1371, p 1371 (2020) Genes |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, lcsh:QH426-470, medicine.drug_class, Review, 030204 cardiovascular system & hematology, Bone Morphogenetic Protein Receptors, Type II, Bone morphogenetic protein, Bioinformatics, 03 medical and health sciences, 0302 clinical medicine, Mediator, estradiol, bone morphogenetic protein receptor type 2, gender, estrogen, Genetics, medicine, Animals, Humans, Bone morphogenetic protein receptor, penetrance, Receptor, Genetics (clinical), Pulmonary Arterial Hypertension, business.industry, familial, Estrogens, PAH, heritable, medicine.disease, Pulmonary hypertension, BMPR2, lcsh:Genetics, medicine.anatomical_structure, 030228 respiratory system, Estrogen, Vascular resistance, Female, business, Signal Transduction |
| الوصف: | Group 1 pulmonary hypertension (pulmonary arterial hypertension; PAH) is a rare disease characterized by remodeling of the small pulmonary arteries leading to progressive elevation of pulmonary vascular resistance, ultimately leading to right ventricular failure and death. Deleterious mutations in the serine-threonine receptor bone morphogenetic protein receptor 2 (BMPR2; a central mediator of bone morphogenetic protein (BMP) signaling) and female sex are known risk factors for the development of PAH in humans. In this narrative review, we explore the complex interplay between the BMP and estrogen signaling pathways, and the potentially synergistic mechanisms by which these signaling cascades increase the risk of developing PAH. A comprehensive understanding of these tangled pathways may reveal therapeutic targets to prevent or slow the progression of PAH. |
| تدمد: | 2073-4425 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd40e1fdbaa4b55f92c673d5a0db58dTest https://doi.org/10.3390/genes11111371Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8fd40e1fdbaa4b55f92c673d5a0db58d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734425 |
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