Immune-Mediated Retinal Vasculitis in Posterior Uveitis and Experimental Models: The Leukotriene (LT)B4-VEGF Axis
| العنوان: | Immune-Mediated Retinal Vasculitis in Posterior Uveitis and Experimental Models: The Leukotriene (LT)B4-VEGF Axis |
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| المؤلفون: | Virginia L. Calder, Wynne Weston-Davies, Malihe Eskandarpour, Miles A. Nunn |
| المصدر: | Cells, Vol 10, Iss 396, p 396 (2021) Cells |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Vascular Endothelial Growth Factor A, 0301 basic medicine, BLT1, LTB4, Leukotriene B4, Receptors, Leukotriene B4, Inflammation, Vascular permeability, Review, neovascularisation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, Humans, lcsh:QH301-705.5, Leukotriene, Retinal vasculitis, business.industry, Retinal, General Medicine, medicine.disease, VEGF, Disease Models, Animal, 030104 developmental biology, chemistry, lcsh:Biology (General), inflammation, EAU, Intraocular fluid, retinal vasculitis, Immunology, 030221 ophthalmology & optometry, uveitis, medicine.symptom, business, Uveitis |
| الوصف: | Retinal vascular diseases have distinct, complex and multifactorial pathogeneses yet share several key pathophysiological aspects including inflammation, vascular permeability and neovascularisation. In non-infectious posterior uveitis (NIU), retinal vasculitis involves vessel leakage leading to retinal enlargement, exudation, and macular oedema. Neovascularisation is not a common feature in NIU, however, detection of the major angiogenic factor—vascular endothelial growth factor A (VEGF-A)—in intraocular fluids in animal models of uveitis may be an indication for a role for this cytokine in a highly inflammatory condition. Suppression of VEGF-A by directly targeting the leukotriene B4 (LTB4) receptor (BLT1) pathway indicates a connection between leukotrienes (LTs), which have prominent roles in initiating and propagating inflammatory responses, and VEGF-A in retinal inflammatory diseases. Further research is needed to understand how LTs interact with intraocular cytokines in retinal inflammatory diseases to guide the development of novel therapeutic approaches targeting both inflammatory mediator pathways. |
| اللغة: | English |
| تدمد: | 2073-4409 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45866ee086c0a84b1966b4c31f4a94cbTest https://www.mdpi.com/2073-4409/10/2/396Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....45866ee086c0a84b1966b4c31f4a94cb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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