Prostaglandin E-Major Urinary Metabolite (PGE-MUM) as a Tumor Marker for Lung Adenocarcinoma
| العنوان: | Prostaglandin E-Major Urinary Metabolite (PGE-MUM) as a Tumor Marker for Lung Adenocarcinoma |
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| المؤلفون: | Mitsuo Hashimoto, Satoru Ito, Kazuyoshi Kuwano, Mutsunori Fujiwara, Yu Fujita, Hirofumi Utsumi, Hiromichi Hara, Jun Araya, Takanori Numata, Hironori Kawamoto, Seiji Arihiro, Shunsuke Minagawa, Tomokazu Matsuura, Hiroshi Wakui, Akihiro Ichikawa |
| المصدر: | Cancers Volume 11 Issue 6 Cancers, Vol 11, Iss 6, p 768 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, medicine.medical_specialty, TNM staging system, lcsh:RC254-282, Gastroenterology, Article, Metastasis, 03 medical and health sciences, 0302 clinical medicine, PGE-MUM, Internal medicine, medicine, Carcinoma, Lung cancer, Tumor marker, Lung, business.industry, Cancer, respiratory system, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lung adenocarcinoma, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, biomarker, Adenocarcinoma, lipids (amino acids, peptides, and proteins), business |
| الوصف: | Background: Prostaglandin E2 (PGE2) is metabolized to prostaglandin E-major urinary metabolite (PGE-MUM). Enhanced cyclooxygenase-2 (COX-2) expression demonstrated in lung adenocarcinoma indicates increased PGE-MUM levels in patients with lung adenocarcinoma. Objectives: We aimed to elucidate the clinical usefulness of measuring PGE-MUM as an indicator of tumor burden in patients with lung adenocarcinoma. Methods: PGE-MUM was measured by a radioimmunoassay in control healthy volunteers (n = 124) and patients with lung adenocarcinoma (n = 54). Associations between PGE-MUM levels and clinical characteristics of the patients (including lung cancer stage and TNM factors (T: Tumor, N: Node, M: Metastasis) were examined. Results: PGE-MUM levels were significantly elevated in patients with lung adenocarcinoma. A PGE-MUM level of 14.9 &mu g/g∙Cr showed 70.4% sensitivity and 67.7% specificity for the diagnosis of lung adenocarcinoma. PGE-MUM levels tended to be positively correlated with cancer progression as determined by the TNM staging system. Advanced stage (stage III, stage IV, and recurrence) was significantly associated with high PGE-MUM levels by logistic regression analysis. No apparent correlation was demonstrated between PGE-MUM and carcinoma embryonic antigen (CEA) levels. Conclusions: PGE-MUM can be a promising biomarker reflecting the systemic tumor burden of lung adenocarcinoma. |
| وصف الملف: | application/pdf |
| تدمد: | 2072-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3249f08af4ea16c7882110e67a0fb4Test https://doi.org/10.3390/cancers11060768Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5a3249f08af4ea16c7882110e67a0fb4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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