A Stage-Based Approach to Therapy in Parkinson’s Disease
| العنوان: | A Stage-Based Approach to Therapy in Parkinson’s Disease |
|---|---|
| المؤلفون: | Mirella Russo, Astrid Thomas, Stefano L. Sensi, Laura Ferri, Fedele Dono, Michela Vitale, Marco Onofrj, Laura Bonanni, Martina Di Pietro, Vincenzo Di Stefano, Claudia Carrarini, Filomena Barbone, Marianna Gabriella Rispoli |
| المساهمون: | Carrarini C., Russo M., Dono F., Pietro M.D., Rispoli M.G., Di Stefano V., Ferri L., Barbone F., Vitale M., Thomas A., Sensi S.L., Onofrj M., Bonanni L. |
| المصدر: | Biomolecules, Vol 9, Iss 8, p 388 (2019) Biomolecules |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Parkinson's disease, Impulse control disorder, lcsh:QR1-502, Review, Disease, l-dopa, Biochemistry, REM sleep behavior disorder, Motor symptoms, lcsh:Microbiology, Antiparkinson Agents, non-pharmacological therapy, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, medicine, Humans, dopamine-agonists, Apathy, anticholinergics, Resting tremor, Molecular Biology, amantadine, business.industry, Amantadine, Parkinson Disease, monoamine oxidase inhibitors, motor symptoms, medicine.disease, non-motor symptoms, 030104 developmental biology, acetylcholinesterase inhibitors, Parkinson’s disease, |
| الوصف: | Parkinson’s disease (PD) is a neurodegenerative disorder that features progressive, disabling motor symptoms, such as bradykinesia, rigidity, and resting tremor. Nevertheless, some non-motor symptoms, including depression, REM sleep behavior disorder, and olfactive impairment, are even earlier features of PD. At later stages, apathy, impulse control disorder, neuropsychiatric disturbances, and cognitive impairment can present, and they often become a heavy burden for both patients and caregivers. Indeed, PD increasingly compromises activities of daily life, even though a high variability in clinical presentation can be observed among people affected. Nowadays, symptomatic drugs and non-pharmaceutical treatments represent the best therapeutic options to improve quality of life in PD patients. The aim of the present review is to provide a practical, stage-based guide to pharmacological management of both motor and non-motor symptoms of PD. Furthermore, warning about drug side effects, contraindications, as well as dosage and methods of administration, are highlighted here, to help the physician in yielding the best therapeutic strategies for each symptom and condition in patients with PD. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316492bedb15671c7f8e2855e8edb79fTest https://www.mdpi.com/2218-273X/9/8/388Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....316492bedb15671c7f8e2855e8edb79f |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |