Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
| العنوان: | Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance |
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| المؤلفون: | Weihua Zhou, Daniel R. Wahl |
| المصدر: | Cancers, Vol 11, Iss 9, p 1231 (2019) Cancers |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, medicine.medical_treatment, Metabolic reprogramming, Brain tumor, Review, urologic and male genital diseases, lcsh:RC254-282, Targeted therapy, 03 medical and health sciences, 0302 clinical medicine, metabolic remodeling, Glioma, glioma, Medicine, metabolic targeting, Treatment resistance, Chemotherapy, business.industry, urogenital system, glioblastoma, Immunotherapy, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, nervous system diseases, radiation, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, business, metabolism, Glioblastoma |
| الوصف: | Glioblastoma (GBM) is the most common and aggressive primary brain tumor and is nearly universally fatal. Targeted therapy and immunotherapy have had limited success in GBM, leaving surgery, alkylating chemotherapy and ionizing radiation as the standards of care. Like most cancers, GBMs rewire metabolism to fuel survival, proliferation, and invasion. Emerging evidence suggests that this metabolic reprogramming also mediates resistance to the standard-of-care therapies used to treat GBM. In this review, we discuss the noteworthy metabolic features of GBM, the key pathways that reshape tumor metabolism, and how inhibiting abnormal metabolism may be able to overcome the inherent resistance of GBM to radiation and chemotherapy. |
| اللغة: | English |
| تدمد: | 2072-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02eb638e67eb793240f03ce97dcc608dTest https://www.mdpi.com/2072-6694/11/9/1231Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....02eb638e67eb793240f03ce97dcc608d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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