Survival Analysis after Living Donor Liver Transplantation for Hepatocellular Carcinoma: A Single Center Cohort Study
| العنوان: | Survival Analysis after Living Donor Liver Transplantation for Hepatocellular Carcinoma: A Single Center Cohort Study |
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| المؤلفون: | Sang-Jae Park, Byung-Gon Na, Seong Hoon Kim |
| المصدر: | Biology Volume 10 Issue 5 Biology, Vol 10, Iss 446, p 446 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, QH301-705.5, medicine.medical_treatment, education, living donor, Milan criteria, Biology, Liver transplantation, Single Center, Gastroenterology, Article, General Biochemistry, Genetics and Molecular Biology, survival analysis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Biology (General), Survival analysis, liver transplantation, General Immunology and Microbiology, Hazard ratio, hepatocellular carcinoma, medicine.disease, digestive system diseases, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, 030211 gastroenterology & hepatology, General Agricultural and Biological Sciences, Living donor liver transplantation, Cohort study |
| الوصف: | Background: Living-donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC) has been used as a curative treatment option for hepatocellular carcinoma (HCC) because of a shortage of deceased donors. This study aimed to investigate survival outcomes after LDLT for HCC. Method: This study included 359 patients undergoing LDLT for HCC. We analyzed overall survival (OS) and recurrence-free survival (RFS) and the prognostic factors related to them. Results: The 5-year OS and RFS rates of patients within the Milan criteria (WM) were better than those of patients beyond the Milan criteria (BM) (87.3% vs. 64.1% and 87.6% vs. 57.8%, respectively, both p < 0.05). Alpha-fetoprotein level (AFP) > 400 ng/mL (hazard ratio (HR), 2.07 95% CI, 1.28–3.36 p < 0.05) and HCC of BM (HR, 2.61 95% CI, 1.60–4.26 0.05) at immediate pretransplant were independent risk factors of OS. AFP > 400 ng/mL (HR, 2.16 95% CI, 1.34–3.49 0.05) and HCC of BM (HR, 3.01 95% CI, 1.81–5.01 0.05) were also independent risk factors of RFS. In pathologic findings of explanted liver, tumor size, Edmondson–Steiner grade III–IV, and microvascular invasion were independent risk factors of both OS and RFS (p < 0.05). Conclusions: BM and AFP > 400 ng/mL at immediate pretransplant are unfavorable predictors of survival outcomes after LDLT for HCC. |
| وصف الملف: | application/pdf |
| تدمد: | 2079-7737 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2a7e7c52451a736565c1d9c0ad76bbTest https://doi.org/10.3390/biology10050446Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ff2a7e7c52451a736565c1d9c0ad76bb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20797737 |
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