دورية أكاديمية
Association between Motor Signs and Cognitive Performance in Cognitively Unimpaired Older Adults: A Cross-Sectional Study Using the NACC Database
| العنوان: | Association between Motor Signs and Cognitive Performance in Cognitively Unimpaired Older Adults: A Cross-Sectional Study Using the NACC Database |
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| المؤلفون: | Siokas V., Liampas I., Lyketsos C.G., Dardiotis E. |
| المصدر: | Brain Sciences ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85140654009&doi=10.3390%2fbrainsci12101365&partnerID=40&md5=b94fb40262f6cba8eadb358b18b36e55Test |
| بيانات النشر: | MDPI MDPI AG Multidisciplinary Digital Publishing Institute |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | antidepressant agent, anxiolytic agent, hypnotic agent, neuroleptic agent, sedative agent, adult, alcohol abuse, Alzheimer disease, anxiety, Article, B12 deficiency, Beck Depression Inventory, body position, bradykinesia, cardiovascular disease, cerebrovascular accident, cerebrovascular disease, cognition, cognitive defect, dementia, depression, disease severity, electrocardiography, episodic memory, female, heart arrest, heart failure, human, language processing, male |
| الوصف: | Aiming to examine whether specific motor signs are associated with worse performance in specific cognitive domains among cognitively unimpaired (CU) individuals, we performed a cross-sectional analysis of data from the baseline evaluations of older, CU participants from the National Alzheimer’s Coordinating Center (NACC) Uniform Data Set. In total, 8149 CU (≥60 years) participants were included. Of these, 905 individuals scored ≥ 2 on at least one of the motor domains of the Unified Parkinson’s Disease Rating Scale part III (UPDRSIII). Cognitively impaired individuals, participants with psychiatric disorders and/or under treatment with antipsychotic, anxiolytic, sedative or hypnotic agents were excluded. Nine motor signs were examined: hypophonia, masked facies, resting tremor, action/postural tremor, rigidity, bradykinesia, impaired chair rise, impaired posture/gait and postural instability. Their association with performance on episodic memory, semantic memory, language, attention, processing speed or executive function was assessed using crude and adjusted linear regression models. Individuals with impaired chair rise had worse episodic memory, semantic memory, processing speed and executive function, while those with bradykinesia had worse language, processing speed and executive function. Sensitivity analyses, by excluding participants with cerebrovascular disease or PD, or other Parkinsonism, produced similar results with the exception of the relationship between bradykinesia and language performance. © 2022 by the authors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://hdl.handle.net/11615/79041Test |
| الإتاحة: | http://hdl.handle.net/11615/79041Test |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.7AC813AB |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |