دورية أكاديمية
The miRNA mirage: How close are we to finding a non-invasive diagnostic biomarker in endometriosis? A systematic review.
| العنوان: | The miRNA mirage: How close are we to finding a non-invasive diagnostic biomarker in endometriosis? A systematic review. |
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| المؤلفون: | Agrawal, S, Tapmeier, T, Rahmioglu, N, Kirtley, S, Zondervan, K, Becker, C |
| بيانات النشر: | MDPI |
| سنة النشر: | 2018 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | Background: Endometriosis is a common disorder of the reproductive age group, characterised by the presence of ectopic endometrial tissue. The disease not only causes enormous suffering to the affected women, but also brings a tremendous medical and economic burden to bear on society. There is a long lag phase between the onset and diagnosis of the disease, mainly due to its non-specific symptoms and the lack of a non-invasive test. Endometriosis can only be diagnosed invasively by laparoscopy. A specific, non-invasive test to diagnose endometriosis is an unmet clinical need. The recent discovery of microRNAs (miRNAs) as modulators of gene expression, and their stability and specificity, make them an attractive candidate biomarker. Various studies on miRNAs in endometriosis have identified their cardinal role in the pathogenesis of the disease, and have proposed them as potential biomarkers in endometriosis. Rationale/Objectives: The aims of this review were to study the role of circulatory miRNAs in endometriosis, and bring to light whether circulatory miRNAs could be potential non-invasive biomarkers to diagnose the disease.Three databases, PubMed, EMBASE, and BIOSIS were searched, using a combination of Mesh or Emtree headings and free-text terms, to identify literature relating to circulating miRNAs in endometriosis published from 1996 to 31 December 2017. Only peer-reviewed, full-text original research articles in English were included in the current review. The studies meeting the inclusion criteria were critically assessed and checked using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies) tool. The dysregulated miRNAs were assessed regarding the concordance between the various studies and their role in the disease.Nine studies were critically analysed, and 42 different miRNAs were found to be dysregulated in them, with only one common miRNA (miR-20a) differentially expressed in more than one study. miR-17-5p/20a, miR-200, miR-199a, miR-143, and miR-145 were explored for their pivotal role ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://ora.ox.ac.uk/objects/uuid:62bcafa0-f832-47da-9cf9-cd9bfd1777f5Test; https://doi.org/10.3390/ijms19020599Test |
| DOI: | 10.3390/ijms19020599 |
| الإتاحة: | https://doi.org/10.3390/ijms19020599Test https://ora.ox.ac.uk/objects/uuid:62bcafa0-f832-47da-9cf9-cd9bfd1777f5Test |
| حقوق: | info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| رقم الانضمام: | edsbas.68B198BD |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms19020599 |
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