Morphological Medial Gastrocnemius Muscle Growth in Ambulant Children with Spastic Cerebral Palsy: A Prospective Longitudinal Study
| العنوان: | Morphological Medial Gastrocnemius Muscle Growth in Ambulant Children with Spastic Cerebral Palsy: A Prospective Longitudinal Study |
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| المؤلفون: | Nathalie De Beukelaer, Ines Vandekerckhove, Ester Huyghe, Geert Molenberghs, Nicky Peeters, Britta Hanssen, Els Ortibus, Anja Van Campenhout, Kaat Desloovere |
| المساهمون: | Molenberghs, Geert/0000-0002-6453-5448, De Beukelaer, Nathalie/0000-0002-7800-3354, Van Campenhout, Anja/0000-0002-8158-5535, De Beukelaer, Nathalie, Vandekerckhove, Ines, Huyghe, Ester, MOLENBERGHS, Geert, Peeters , Nicky, Hanssen, Britta, Ortibus, Els, Van Campenhout, Anja, Desloovere, Kaat |
| المصدر: | Journal of Clinical Medicine Volume 12 Issue 4 Pages: 1564 |
| بيانات النشر: | MDPI, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | cerebral palsy, cross-sectional area, GMFCS, muscle volume, pediatrics, ultrasound, piecewise model, General Medicine |
| الوصف: | Only cross-sectional studies have demonstrated muscle deficits in children with spastic cerebral palsy (SCP). The impact of gross motor functional limitations on altered muscle growth remains unclear. This prospective longitudinal study modelled morphological muscle growth in 87 children with SCP (age range 6 months to 11 years, Gross Motor Function Classification System [GMFCS] level I/II/III = 47/22/18). Ultrasound assessments were performed during 2-year follow-up and repeated for a minimal interval of 6 months. Three-dimensional freehand ultrasound was applied to assess medial gastrocnemius muscle volume (MV), mid-belly cross-sectional area (CSA) and muscle belly length (ML). Non-linear mixed models compared trajectories of (normalized) muscle growth between GMFCS-I and GMFCS-II&III. MV and CSA growth trajectories showed a piecewise model with two breakpoints, with the highest growth before 2 years and negative growth rates after 6-9 years. Before 2 years, children with GMFCS-II&III already showed lower growth rates compared to GMFCS-I. From 2 to 9 years, the growth rates did not differ between GMFCS levels. After 9 years, a more pronounced reduction in normalized CSA was observed in GMFCS-II&III. Different trajectories in ML growth were shown between the GMFCS level subgroups. These longitudinal trajectories highlight monitoring of SCP muscle pathology from early ages and related to motor mobility. Treatment planning and goals should stimulate muscle growth. ND was funded by an internal KU Leuven grant, Belgium, 3D-MMAP-C24/18/103. This work was further supported by Internal funding of KU Leuven Biomedical Sciences Group: Fund for Translational Biomedical Research, Belgium, 2019 and the Research Foundation Flanders (FWO), Belgium, G0B4619N. BH and NP were funded by a TBM grant (TAMTA-T005416N). IV was funded through a research fellowship from FWO (1188921N). The authors wish to thank Heidi Devolder and Julie Uytterhoeven for assistance in patient recruitment and planning of the follow-up appointments. We would like to thank Jorieke Deschrevel for the support during the data acquisition and Tijl Dewit for the support of 3DfUS measures and database management. |
| وصف الملف: | application/pdf; Electronic |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bace8c92c0e9a4b684bc26660065988Test http://hdl.handle.net/1942/39831Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6bace8c92c0e9a4b684bc26660065988 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |