Mitochondrial OXPHOS Biogenesis: Co-Regulation of Protein Synthesis, Import, and Assembly Pathways
| العنوان: | Mitochondrial OXPHOS Biogenesis: Co-Regulation of Protein Synthesis, Import, and Assembly Pathways |
|---|---|
| المؤلفون: | Monika Oláhová, Jia Xin Tang, Robert W. Taylor, Kyle Thompson |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 3820, p 3820 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, mitochondrial ACP, Mitochondrial translation, Amino Acid Motifs, Review, Oxidative Phosphorylation, lcsh:Chemistry, Mice, 0302 clinical medicine, Cytosol, Gene expression, Protein biosynthesis, lcsh:QH301-705.5, Spectroscopy, Organelle Biogenesis, biology, Chemistry, Nuclear Proteins, General Medicine, OXPHOS biogenesis, Computer Science Applications, Cell biology, Mitochondria, Acyl carrier protein, Protein Transport, mitochondrial gene expression, Transcriptional Activation, Mitochondrial DNA, Oxidative phosphorylation, OXPHOS assembly factors, DNA, Mitochondrial, Catalysis, Inorganic Chemistry, Electron Transport Complex IV, Mitochondrial Proteins, 03 medical and health sciences, Protein Domains, Species Specificity, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, Mitochondrial protein, Cell Nucleus, Organic Chemistry, LYRM proteins, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Gene Expression Regulation, Protein Biosynthesis, biology.protein, 030217 neurology & neurosurgery, Biogenesis, mitochondrial import |
| الوصف: | The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an intricate process, which—given their dual-genetic control—requires tight co-regulation of two evolutionarily distinct gene expression machineries. Moreover, fine-tuning protein synthesis to the nascent assembly of OXPHOS complexes requires regulatory mechanisms such as translational plasticity and translational activators that can coordinate mitochondrial translation with the import of nuclear-encoded mitochondrial proteins. The intricacy of OXPHOS complex biogenesis is further evidenced by the requirement of many tightly orchestrated steps and ancillary factors. Early-stage ancillary chaperones have essential roles in coordinating OXPHOS assembly, whilst late-stage assembly factors—also known as the LYRM (leucine–tyrosine–arginine motif) proteins—together with the mitochondrial acyl carrier protein (ACP)—regulate the incorporation and activation of late-incorporating OXPHOS subunits and/or co-factors. In this review, we describe recent discoveries providing insights into the mechanisms required for optimal OXPHOS biogenesis, including the coordination of mitochondrial gene expression with the availability of nuclear-encoded factors entering via mitochondrial protein import systems. |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee29209f50eca226e3bc499c0722f81Test http://europepmc.org/articles/PMC7312649Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9ee29209f50eca226e3bc499c0722f81 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
|---|