Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and Joints
| العنوان: | Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and Joints |
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| المؤلفون: | Gabriele Gallo Afflitto, Marie-Astrid Boutet, Alessandra Nerviani, Costantino Pitzalis |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 19, Iss 2, p 530 (2018) |
| بيانات النشر: | MDPI, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, interleukine-23, Inflammation, Disease, Review, medicine.disease_cause, Interleukin-23, Catalysis, Autoimmunity, Inorganic Chemistry, lcsh:Chemistry, 03 medical and health sciences, Psoriatic skin, Psoriatic arthritis, 0302 clinical medicine, Psoriasis, Interleukin 23, Medicine, Animals, Humans, Physical and Theoretical Chemistry, Th17 cells, Precision Medicine, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, Skin, 030203 arthritis & rheumatology, psoriatic arthritis, Biological Products, business.industry, Organic Chemistry, Arthritis, Psoriatic, Interleukin-17, General Medicine, psoriasis, medicine.disease, Computer Science Applications, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Immunology, Joints, Interleukin 17, medicine.symptom, business |
| الوصف: | Psoriasis is a chronic systemic inflammatory disease causing erythematosus and scaly skin plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is characterised by inflammation and progressive damage of the peripheral joints and/or the spine and/or the entheses. The pathogenic mechanisms driving the skin disorder in psoriasis and the joint disease in PsA are sustained by the activation of inflammatory pathways that can be overlapping, but also, at least partially, distinct. Cytokines members of the IL-23/IL-17 family, critical in the development of autoimmunity, are abundantly expressed within the cutaneous lesions but also seem to be involved in chronic inflammation and damage of the synovium though, as it will be here discussed, not in all patients. In this review, we will focus on the state of the art of the molecular features of psoriatic skin and joints, focusing on the specific role of the IL-23/IL-17 pathway in each of these anatomical districts. We will then offer an overview of the approved and in-development biologics targeting this axis, emphasising how the availability of the “target” in the diseased tissues could provide a plausible explanation for the heterogeneous clinical efficacy of these drugs, thus opening future perspective of personalised therapies. |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6c95836731a770ef6583c969a10267Test http://europepmc.org/articles/PMC5855752Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0c6c95836731a770ef6583c969a10267 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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