دورية أكاديمية
Complex Polysaccharide-Based Nanocomposites for Oral Insulin Delivery
| العنوان: | Complex Polysaccharide-Based Nanocomposites for Oral Insulin Delivery |
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| المؤلفون: | Collado-González, Mar, Ferreri, M. Cristina, Freitas, Alessandra, Santos, Ana Cláudia, Ferreira, Nuno Ricardo Esteves, Carissimi, Guzmán, Sequeira, Joana A. D., Díaz Baños, F. Guillermo, Villora, Gloria, Veiga, Francisco, Ribeiro, António |
| بيانات النشر: | MDPI |
| سنة النشر: | 2020 |
| المجموعة: | Universidade de Coimbra: Estudo Geral |
| مصطلحات موضوعية: | chitosan, alginate polysaccharide nanocomposite, stability, LUMiSizer, Administration, Oral, Alginates, Drug Carriers, Drug Delivery Systems, Gels, Insulin, Nanocomposites, Polyethylene Glycols, Polysaccharides, Serum Albumin, Bovine, Static Electricity |
| الوصف: | Polyelectrolyte nanocomposites rarely reach a stable state and aggregation often occurs. Here, we report the synthesis of nanocomposites for the oral delivery of insulin composed of alginate, dextran sulfate, poly-(ethylene glycol) 4000, poloxamer 188, chitosan, and bovine serum albumin. The nanocomposites were obtained by Ca2+-induced gelation of alginate followed by an electrostatic-interaction process among the polyelectrolytes. Chitosan seemed to be essential for the final size of the nanocomposites and there was an optimal content that led to the synthesis of nanocomposites of 400-600 nm hydrodynamic size. The enhanced stability of the synthesized nanocomposites was assessed with LUMiSizer after synthesis. Nanocomposite stability over time and under variations of ionic strength and pH were assessed with dynamic light scattering. The rounded shapes of nanocomposites were confirmed by scanning electron microscopy. After loading with insulin, analysis by HPLC revealed complete drug release under physiologically simulated conditions. ; This work has been partially supported from the European Commission (FEDER/ERDF) and the Spanish Ministry of Economy and Competitiveness (MINECO) (ref CTQ2017-87708-R) and by the Fundación Séneca del Centro de Coordinación de la Investigación de la Región de Murcia under projects 20977/PI/18 and by the Nils Coordinated Mobility under grant 012-ABEL-CM-2014A. Mar Collado-González acknowledges the fellowship for postdoctoral training (20381/PD/17) funded by the Consejería de Empleo, Universidades y Empresa de la Comunidad Autónoma de la Región de Murcia (CARM), through the Fundación Séneca de la Región de Murcia and for the support from the University of Murcia for stays abroad of young researchers and doctoral students in the action lines of Campus Mare Nostrum (R273/2016). Alessandra R. Freitas acknowledges support from the Brazilian National Council for Scientific and Technological Development (BolsistaCNPq-Brasil). Ana Cláudia Santos acknowledges support from the Portuguese ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1660-3397 |
| العلاقة: | http://hdl.handle.net/10316/106356Test |
| DOI: | 10.3390/md18010055 |
| الإتاحة: | https://doi.org/10.3390/md18010055Test http://hdl.handle.net/10316/106356Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B1B9F143 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16603397 |
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| DOI: | 10.3390/md18010055 |