Anemia in Crohn’s Disease—The Unseen Face of Inflammatory Bowel Disease
| العنوان: | Anemia in Crohn’s Disease—The Unseen Face of Inflammatory Bowel Disease |
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| المؤلفون: | Otilia Gavrilescu, Iolanda Valentina Popa, Cristina Cijevschi Prelipcean, Mariana Floria, Lucian Boiculese, Catalina Mihai, Mihaela Dranga, Oana Irina Gavril, Oana-Bogdana Bărboi, Anca Trifan |
| المصدر: | Medicina Medicina, Vol 57, Iss 1046, p 1046 (2021) Volume 57 Issue 10 |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Crohn’s disease, medicine.medical_specialty, Medicine (General), Anemia, Colonoscopy, Disease, Inflammatory bowel disease, Severity of Illness Index, Article, law.invention, R5-920, Quality of life, Crohn Disease, Capsule endoscopy, law, Internal medicine, medicine, Humans, Prospective Studies, Prospective cohort study, Crohn's disease, medicine.diagnostic_test, business.industry, General Medicine, medicine.disease, Inflammatory Bowel Diseases, quality of life, Female, business |
| الوصف: | Background and Objectives: Anemia is the most frequent complication of inflammatory bowel diseases. Clinically, anemia can affect important quality-of-life (QoL) components, such as exercise capacity, cognitive function, and the ability to carry out social activities. The disease activity has a significant impact on QoL, mainly due to clinical manifestations, which are more severe during the periods of disease activity. Our aim was to estimate the impact of anemia on QoL in patients with Crohn’s disease. Material and Methods. We made a prospective study on 134 patients with Crohn’s disease (CD) in a Romanian tertiary center. The CD diagnosis was established by colonoscopy and histopathological examination. In particular cases, additional examinations were required (small bowel capsule endoscopy, computed tomography enterography, and magnetic resonance enterography). Anemia was defined according to the World Health Organization’s definition, the activity of the disease was assessed by Crohn’s disease activity index (CDAI) score, and the QoL was evaluated by Inflammatory Bowel Disease Questionnaire 32 (IBDQ 32). Results: 44.8% patient had anemia, statistically related to the activity of the disease and corticoids use. We found a strong association between QoL and disease activity on all four sub-scores: patients with more severe activity had a significantly lower IBDQ (260.38 ± 116.96 vs. 163.85 ± 87.20, p = 0.001) and the presence of anemia (127.03 vs. 148.38, p = 0.001). In multiple regression analyses, both disease activity and anemia had an impact on the QoL. Conclusions: Anemia has high prevalence in the CD in northeastern region of Romania. Anemia was more common in female patients, in patients undergoing corticosteroid treatment, and in those with active disease. Both anemia and disease activity had a strong negative and independent impact on QoL. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1648-9144 1010-660X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95df0601172c875642a4a36d1a5630ecTest http://europepmc.org/articles/PMC8539193Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....95df0601172c875642a4a36d1a5630ec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16489144 1010660X |
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