Hes5.9 Coordinate FGF and Notch Signaling to Modulate Gastrulation via Regulating Cell Fate Specification and Cell Migration in Xenopus tropicalis
| العنوان: | Hes5.9 Coordinate FGF and Notch Signaling to Modulate Gastrulation via Regulating Cell Fate Specification and Cell Migration in Xenopus tropicalis |
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| المؤلفون: | Peichao Chen, Xiao Huang, Liyue Zhang, Yongpu Zhang, Mingjiang Wu, Shanshan Yang |
| المصدر: | Genes Volume 11 Issue 11 Genes, Vol 11, Iss 1363, p 1363 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Notch, lcsh:QH426-470, cell migration, Notch signaling pathway, HES5, Germ layer, Biology, Cell fate determination, Fibroblast growth factor, Article, Hes5.9, 03 medical and health sciences, Genetics, FGF, gastrulation, Genetics (clinical), cell fate specification, 030102 biochemistry & molecular biology, Mesodermal cell fate specification, Wnt signaling pathway, Cell biology, Gastrulation, lcsh:Genetics, 030104 developmental biology |
| الوصف: | Gastrulation drives the establishment of three germ layers and embryonic axes during frog embryonic development. Mesodermal cell fate specification and morphogenetic movements are vital factors coordinating gastrulation, which are regulated by numerous signaling pathways, such as the Wnt (Wingless/Integrated), Notch, and FGF (Fibroblast growth factor) pathways. However, the coordination of the Notch and FGF signaling pathways during gastrulation remains unclear. We identified a novel helix&ndash loop&ndash helix DNA binding domain gene (Hes5.9), which was regulated by the FGF and Notch signaling pathways during gastrulation. Furthermore, gain- and loss-of-function of Hes5.9 led to defective cell migration and disturbed the expression patterns of mesodermal and endodermal marker genes, thus interfering with gastrulation. Collectively, these results suggest that Hes5.9 plays a crucial role in cell fate decisions and cell migration during gastrulation, which is modulated by the FGF and Notch signaling pathways. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2073-4425 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df34286e05cea68da36d275ec8934b36Test http://europepmc.org/articles/PMC7699193Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....df34286e05cea68da36d275ec8934b36 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734425 |
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