التفاصيل البيبلوغرافية
| العنوان: |
Immunohistochemical Glucagon-like Peptide-1 Receptor Expression in Human Insulinomas. |
| المؤلفون: |
Vesterinen, Tiina, Peltola, Elina, Leijon, Helena, Hannula, Päivi, Huhtala, Heini, Mäkinen, Markus J., Nieminen, Lasse, Pirinen, Elina, Rönty, Mikko, Söderström, Mirva, Jaatinen, Pia, Arola, Johanna |
| المصدر: |
International Journal of Molecular Sciences; Oct2023, Vol. 24 Issue 20, p15164, 9p |
| مصطلحات موضوعية: |
GLUCAGON-like peptide-1 receptor, SOMATOSTATIN receptors, NEUROENDOCRINE tumors, OVERALL survival, GLUCAGON receptors |
| مستخلص: |
Insulinomas are rare functional pancreatic neuroendocrine tumours, which metastasize in 10% of cases. As predicting the prognosis can be challenging, there is a need for the determination of clinicopathological factors associated with metastatic potential. The aim of this study is to evaluate the glucagon-like peptide-1 receptor (GLP-1R) expression in insulinomas and to analyse its association with clinicopathological features and patient outcome. This retrospective study involves pancreatic tumour tissue samples from fifty-two insulinoma patients. After histological re-evaluation, formalin-fixed paraffin-embedded tissue samples were processed into tissue microarrays and stained immunohistochemically with a monoclonal GLP-1R antibody. Forty-eight of the forty-nine (98%) non-metastatic tumours expressed GLP-1R, while one non-metastatic, multiple endocrine neoplasia type 1 (MEN1)-related tumour and all three of the metastatic tumours lacked GLP-1R expression. The lack of GLP-1R expression was associated with impaired overall survival, larger tumour diameter, higher Ki-67 PI and weaker insulin staining. Somatostatin receptor 1–5 expression did not differ between GLP-1R-positive and GLP-1R-negative insulinomas. In conclusion, the lack of GLP-1R expression is associated with metastatic disease and impaired survival in insulinoma patients. Thus, GLP-1R expression could be a useful biomarker in estimating the metastatic potential of the tumour and the prognosis of surgically treated patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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