Serum miR-373-3p and miR-194-5p Are Associated with Early Tumor Progression during FOLFIRINOX Treatment in Pancreatic Cancer Patients: A Prospective Multicenter Study
| العنوان: | Serum miR-373-3p and miR-194-5p Are Associated with Early Tumor Progression during FOLFIRINOX Treatment in Pancreatic Cancer Patients: A Prospective Multicenter Study |
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| المؤلفون: | Fleur van der Sijde, Marjolein Y. V. Homs, Marlies L. van Bekkum, Thierry P. P. van den Bosch, Koop Bosscha, Marc G. Besselink, Bert A. Bonsing, Jan Willem B. de Groot, Thomas M. Karsten, Bas Groot Koerkamp, Brigitte C. M. Haberkorn, Saskia A. C. Luelmo, Leonie J. M. Mekenkamp, Dana A. M. Mustafa, Johanna W. Wilmink, Casper H. J. van Eijck, Eveline E. Vietsch, on behalf of the Dutch Pancreatic Cancer Group |
| المساهمون: | Surgery, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Oncology, CCA - Cancer biology and immunology, Medical Oncology, Pathology |
| المصدر: | International Journal of Molecular Sciences International journal of molecular sciences, 22(20):10902. Multidisciplinary Digital Publishing Institute (MDPI) International Journal of Molecular Sciences, Vol 22, Iss 10902, p 10902 (2021) Volume 22 Issue 20 International Journal of Molecular Sciences, 22(20). MDPI International Journal of Molecular Sciences, 22(20):10902. Multidisciplinary Digital Publishing Institute (MDPI) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, Male, FOLFIRINOX, medicine.medical_treatment, pancreatic cancer, Leucovorin, miR-373, Antineoplastic Combined Chemotherapy Protocols, Prospective Studies, Stage (cooking), Biology (General), predictive biomarker, Spectroscopy, Aged, 80 and over, General Medicine, Middle Aged, Computer Science Applications, Gene Expression Regulation, Neoplastic, Oxaliplatin, Chemistry, Cohort, Disease Progression, Female, Fluorouracil, Adult, medicine.medical_specialty, QH301-705.5, Irinotecan, Catalysis, Article, Inorganic Chemistry, miR-194, SDG 3 - Good Health and Well-being, Internal medicine, Pancreatic cancer, medicine, Biomarkers, Tumor, Humans, Antigens, Tumor-Associated, Carbohydrate, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, Aged, Chemotherapy, business.industry, Organic Chemistry, Odds ratio, medicine.disease, Pancreatic Neoplasms, MicroRNAs, Tumor progression, Multivariate Analysis, business, Progressive disease |
| الوصف: | In this study, we explored the predictive value of serum microRNA (miRNA) expression for early tumor progression during FOLFIRINOX chemotherapy and its association with overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC). A total of 132 PDAC patients of all disease stages were included in this study, of whom 25% showed progressive disease during FOLFIRINOX according to the RECIST criteria. MiRNA expression was analyzed in serum collected before the start and after one cycle of chemotherapy. In the discovery cohort (n = 12), a 352-miRNA RT-qPCR panel was used. In the validation cohorts (total n = 120), miRNA expression was detected using individual RT-qPCR miRNA primers. Before the start of FOLFIRINOX, serum miR-373-3p expression was higher in patients with progressive disease compared to patients with disease control after FOLFIRINOX (Log2 fold difference (FD) 0.88, p = 0.006). MiR-194-5p expression after one cycle of FOLFIRINOX was lower in patients with progressive disease (Log2 FD −0.29, p = 0.044). Both miRNAs were predictors of early tumor progression in a multivariable model including disease stage and baseline CA19-9 level (miR-373-3p odds ratio (OR) 3.99, 95% CI 1.10–14.49 miR-194-5p OR 0.91, 95% CI 0.83–0.99). MiR-373-3p and miR-194-5p did not show an association with OS after adjustment for disease stage, baseline CA19-9, and chemotherapy response. In conclusion, high serum miR-373-3p before the start and low serum miR-194-5p after one cycle are associated with early tumor progression during FOLFIRINOX. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1fb1d176a248b64897bf45002c7021Test http://europepmc.org/articles/PMC8535910Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6d1fb1d176a248b64897bf45002c7021 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 16616596 |
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