Loss of p16: A Bouncer of the Immunological Surveillance?
| العنوان: | Loss of p16: A Bouncer of the Immunological Surveillance? |
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| المؤلفون: | Katherine M. Aird, Raquel Buj, Naveen Kumar Tangudu, Kelly E. Leon |
| المصدر: | Life Life, Vol 11, Iss 309, p 309 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Senescence, Chemokine, chemotherapy resistance, senescence, Regulator, Review, Biology, General Biochemistry, Genetics and Molecular Biology, law.invention, Downregulation and upregulation, law, Transcriptional regulation, melanoma, pancreatic adenocarcinoma, lcsh:Science, Ecology, Evolution, Behavior and Systematics, Paleontology, senescence-associated secretory phenotype (SASP), Cell cycle, Phenotype, cell-cycle, Space and Planetary Science, tumor infiltration, biology.protein, Cancer research, Suppressor, lcsh:Q |
| الوصف: | p16INK4A (hereafter called p16) is an important tumor suppressor protein frequently suppressed in human cancer and highly upregulated in many types of senescence. Although its role as a cell cycle regulator is very well delineated, little is known about its other non-cell cycle-related roles. Importantly, recent correlative studies suggest that p16 may be a regulator of tissue immunological surveillance through the transcriptional regulation of different chemokines, interleukins and other factors secreted as part of the senescence-associated secretory phenotype (SASP). Here, we summarize the current evidence supporting the hypothesis that p16 is a regulator of tumor immunity. |
| اللغة: | English |
| تدمد: | 2075-1729 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e776079876ac8514ef554a2255dd6428Test http://europepmc.org/articles/PMC8065641Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e776079876ac8514ef554a2255dd6428 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20751729 |
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