Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet
| العنوان: | Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet |
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| المؤلفون: | Plácido Navas, Tung Bui Thanh, Luis Fang, Juan Diego Hernández-Camacho, Elisabet Rodríguez-Bies, Ana Belén Cortés-Rodríguez, Guillermo López-Lluch, Catherine Meza-Torres |
| المساهمون: | Ministerio de Educación, Cultura y Deporte (España) |
| المصدر: | Antioxidants Antioxidants, Vol 9, Iss 431, p 431 (2020) Digital.CSIC. Repositorio Institucional del CSIC instname Volume 9 Issue 5 |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, antioxidant, Physiology, Clinical Biochemistry, PINK1, Mitochondrion, Resveratrol, resveratrol, liver, Biochemistry, Parkin, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Mitophagy, Gene expression, medicine, Molecular Biology, Chemistry, Cholesterol, lcsh:RM1-950, food and beverages, Coenzyme Q, Cell Biology, Metabolism, Mitochondria, mitochondria, High-fat diet, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, Endocrinology, high-fat diet, Liver, Antioxidant, coenzyme Q, 030217 neurology & neurosurgery |
| الوصف: | Resveratrol (RSV) is a bioactive natural molecule that induces antioxidant activity and increases protection against oxidative damage. RSV could be used to mitigate damages associated to metabolic diseases and aging. Particularly, RSV regulates different aspects of mitochondrial metabolism. However, no information is available about the effects of RSV on Coenzyme Q (CoQ), a central component in the mitochondrial electron transport chain. Here, we report for the first time that RSV modulates COQ genes and parameters associated to metabolic syndrome in mice. Mice fed with high fat diet (HFD) presented a higher weight gain, triglycerides (TGs) and cholesterol levels while RSV reverted TGs to control level but not weight or cholesterol. HFD induced a decrease of COQs gene mRNA level, whereas RSV reversed this decrease in most of the COQs genes. However, RSV did not show effect on CoQ9, CoQ10 and total CoQ levels, neither in CoQ-dependent antioxidant enzymes. HFD influenced mitochondrial dynamics and mitophagy markers. RSV modulated the levels of PINK1 and PARKIN and their ratio, indicating modulation of mitophagy. In summary, we report that RSV influences some of the metabolic adaptations of HFD affecting mitochondrial physiology while also regulates COQs gene expression levels in a process that can be associated with mitochondrial dynamics and turnover. J.D.H.C. is a predoctoral research fellow from the Spanish Ministry of Education, Culture and Sports [FPU16/03264]. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-3921 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ddcbcbb37be3881a99bdc1088c51acTest http://europepmc.org/articles/PMC7278683Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....63ddcbcbb37be3881a99bdc1088c51ac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763921 |
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