التفاصيل البيبلوغرافية
| العنوان: |
Epigallocatechin-3-O-(3-O-methyl)-gallate-induced Differentiation of Human Keratinocytes Involves Klotho-Mediated Regulation of Protein Kinase-cAMP Responsive Element-Binding Protein Signaling. |
| المؤلفون: |
Hyoung-June Kim, Huikyoung Chang, Seung Hun Han, Min Seuk Lee, Ji-Yong Jung, SoonAe An, Seok-Yun Baek, Jin Ho Lee, John Hwan Lee, Tae Ryong Lee, Dong Wook Shin, Hongtae Kim |
| المصدر: |
International Journal of Molecular Sciences; Apr2014, Vol. 15 Issue 4, p5749-5761, 13p, 1 Color Photograph, 2 Diagrams, 2 Graphs |
| مصطلحات موضوعية: |
EPIGALLOCATECHIN gallate, CELL differentiation, KERATINOCYTES, PROTEIN kinases, CREB protein, CELLULAR signal transduction |
| مستخلص: |
(-)-Epigallocatechin-3-O-gallate (EGCG) has long been known as a potent inducer of keratinocyte differentiation. Although its molecular mechanisms have been extensively studied, its actions on human skin remain to be elucidated. In this study, we demonstrated that methylated EGCG and EGCG increase the expression of klotho, and that klotho functions as a downstream target of EGCG and methylated EGCG in keratinocyte differentiation. We demonstrated that methylated EGCG3 and EGCG induce morphological changes in normal human epidermal keratinocytes (NHEKs) that are related to up-regulation of klotho expression. We also demonstrated that a klotho-induced keratinocyte differentiation marker in NHEKs is inhibited by H-89, a protein kinase (PKA) inhibitor. These results suggest that methylated EGCG and EGCG may function as inducers of keratinocyte differentiation via transcriptional regulation of the klotho protein. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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