In Vitro Methodologies to Study the Role of Advanced Glycation End Products (AGEs) in Neurodegeneration
| العنوان: | In Vitro Methodologies to Study the Role of Advanced Glycation End Products (AGEs) in Neurodegeneration |
|---|---|
| المؤلفون: | Marialena Chrysanthou, Ignacio Miro Estruch, Ivonne M. C. M. Rietjens, Harry J. Wichers, Tamara Hoppenbrouwers |
| المصدر: | Nutrients Nutrients 14 (2022) 2 Nutrients, Vol 14, Iss 363, p 363 (2022) Nutrients, 14(2) |
| بيانات النشر: | MDPI, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Glycation End Products, Advanced, Multiple Sclerosis, Receptor for Advanced Glycation End Products, Review, Toxicology, blood–brain barrier, AGEs, Monocytes, neuroinflammation, Cell Line, Blood–brain barrier, Mice, Neuroinflammation, Alzheimer Disease, Levensmiddelenchemie, Animals, Humans, TX341-641, Neurodegeneration, neuro–immune axis, Advanced glycation end products, Toxicologie, VLAG, Food, Health & Consumer Research, in vitro models, Inflammation, Neurons, WIMEK, Nutrition and Dietetics, Food Chemistry, Nutrition. Foods and food supply, advanced glycation end products, Amyotrophic Lateral Sclerosis, neurodegeneration, Neurodegenerative Diseases, Parkinson Disease, In vitro models, Diet, Rats, Health & Consumer Research, Food Quality and Design, Food, inflammation, Blood-Brain Barrier, Neuroinflammatory Diseases, Neuro–immune axis, Microglia, Food Science |
| الوصف: | Advanced glycation end products (AGEs) can be present in food or be endogenously produced in biological systems. Their formation has been associated with chronic neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis. The implication of AGEs in neurodegeneration is related to their ability to bind to AGE-specific receptors and the ability of their precursors to induce the so-called “dicarbonyl stress”, resulting in cross-linking and protein damage. However, the mode of action underlying their role in neurodegeneration remains unclear. While some research has been carried out in observational clinical studies, further in vitro studies may help elucidate these underlying modes of action. This review presents and discusses in vitro methodologies used in research on the potential role of AGEs in neuroinflammation and neurodegeneration. The overview reveals the main concepts linking AGEs to neurodegeneration, the current findings, and the available and advisable in vitro models to study their role. Moreover, the major questions regarding the role of AGEs in neurodegenerative diseases and the challenges and discrepancies in the research field are discussed. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf84fb02ad8bc29b80f6f8bbbcfa3e55Test http://europepmc.org/articles/PMC8777776Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cf84fb02ad8bc29b80f6f8bbbcfa3e55 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
|---|