Expanding the Neurological Phenotype of Ring Chromosome 10 Syndrome: A Case Report and Review of the Literature
| العنوان: | Expanding the Neurological Phenotype of Ring Chromosome 10 Syndrome: A Case Report and Review of the Literature |
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| المؤلفون: | Chiara Locatelli, Lucia Maltoni, Hodman Ahmed Sheikh Maye, Claudio Graziano, Jacopo Pruccoli, Duccio Maria Cordelli |
| المساهمون: | Pruccoli J., Graziano C., Locatelli C., Maltoni L., Sheikh Maye H.A., Cordelli D.M. |
| المصدر: | Genes Volume 12 Issue 10 Genes, Vol 12, Iss 1513, p 1513 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microcephaly, Pediatrics, Ring Chromosome, ZMYND11, Neurology, magnetic resonance imaging (MRI), Transcription Factor, Developmental Disabilities, Ring chromosome, Cell Cycle Proteins, Chromosome Disorders, QH426-470, r10, Intellectual disability, Cell Cycle Protein, Medicine, Ring Chromosomes, Genetics (clinical), Neuroradiology, Brain, Syndrome, Hypotonia, DNA-Binding Proteins, medicine.anatomical_structure, Phenotype, Child, Preschool, Female, medicine.symptom, Co-Repressor Proteins, Human, medicine.medical_specialty, DNA-Binding Protein, Developmental Disabilitie, r(10), Short stature, Co-Repressor Protein, Article, Intellectual Disability, EBF3, Genetics, neuroradiology, Humans, business.industry, Chromosomes, Human, Pair 10, neurology, medicine.disease, Chromosome Disorder, Posterior cranial fossa, business, ring chromosome 10, Transcription Factors |
| الوصف: | Ring chromosome 10 [r(10)] syndrome is a rare genetic condition, currently described in the medical literature in a small number of case report studies. Typical clinical features include microcephaly, short stature, facial dysmorphisms, ophthalmologic abnormalities and genitourinary malformations. We report a novel case of r(10) syndrome and review the neurological and neuroradiological phenotypes of the previously described cases. Our patient, a 3 year old Italian girl, represents the 20th case of r(10) syndrome described to date. Intellectual disability/developmental delay (ID/DD), microcephaly, strabismus, hypotonia, stereotyped/aggressive behaviors and electroencephalographic abnormalities were identified in our patient, and in a series of previous cases. A brain MRI disclosed a complex malformation involving both the vermis and cerebellar hemispheres in the literature, posterior cranial fossa abnormalities were documented by CT scan in another case. Two genes deleted in our case (ZMYND11 in 10p and EBF3 in 10q) are involved in autosomal dominant neurodevelopmental disorders, characterized by different expressions of brain and posterior cranial fossa abnormalities, ID/DD, hypotonia and behavioral problems. Our case expands the neurological and neuroradiological phenotype of r(10) syndrome. Although r(10) syndrome represents an extremely rare condition, with a clinical characterization limited to case reports, the recurrence of specific neurological and neuroradiological features suggests the need for specific genotype-phenotype studies. |
| وصف الملف: | application/pdf; ELETTRONICO |
| اللغة: | English |
| تدمد: | 2073-4425 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ab9d8d24d2f9f92a86b19708123132Test http://europepmc.org/articles/PMC8535287Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....15ab9d8d24d2f9f92a86b19708123132 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734425 |
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