التفاصيل البيبلوغرافية
| العنوان: |
Application of a Novel Film Sealant Technology for Penetrating Corneal Wounds: An Ex-Vivo Study. |
| المؤلفون: |
Tan, Jackie, Foster, Leslie John Ray, Watson, Stephanie Louise |
| المصدر: |
Applied Sciences (2076-3417); May2020, Vol. 10 Issue 9, p3193, 10p |
| مصطلحات موضوعية: |
PENETRATING wounds, SURFACE coatings, DENTAL adhesives, FLUID pressure, MEDICAL lasers, CATARACT surgery, THIN films |
| مستخلص: |
Featured Application: This novel chitosan film sealant is capable of closing penetrating corneal wounds after routine cataract surgeries, closing traumatic corneal lacerations from battlefield injuries, and replacing sutures in corneal grafting procedures. Aim: To compare the burst pressures of corneal wounds closed with a laser-activated, chitosan-based thin film adhesive against self-seal, sutures and cyanoacrylate. Methods: 2, 4 or 6 mm penetrating corneal wounds were created on 100 freshly enucleated bovine eyes. The wounds were closed using a laser-activated chitosan adhesive (n = 30), self-sealed (control) (n = 30), sutures (n = 20) or cyanoacrylate glue (Histoacryl®) (n = 20). The corneoscleral rim was dissected and mounted onto a custom burst pressure testing chamber. Water was pumped into the chamber at 9ml/hr. The fluid pressure prior to wound leakage was recorded as the 'burst pressure'. Results: The burst pressure for the 2, 4 and 6 mm wounds were 239.2 mmHg (SD = ±102.4), 181.7 mmHg (SD = ±72.8) and 77.4 mmHg (SD = ±37.4) (p < 0.00001), respectively, for chitosan adhesive. Burst pressure was 36.4 mmHg (SD = ±14.7), 4.8 mmHg (SD = ±4.9) and 2.7 mmHg (SD = ±1.3) (p < 0.00001), respectively, for the self-sealed group. For 4 and 6mm wounds, burst pressures with sutures were 33.0 mmHg (SD = ±19) and 23.5 mmHg (SD = ±17.4) (p = 0.0087), respectively. For cyanoacrylate, burst pressures for 2 and 4 mm wounds were 698 mmHg (SD = ±240.3) and 494.3 mmHg (SD = ±324.6) (p = 0.020087), respectively. Conclusion: This laser-activated chitosan-based adhesive sealed bovine corneal wounds up to 6 mm in length. Burst pressure was higher for the adhesive than sutured or self-sealed wounds, but lower than for cyanoacrylate. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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