دورية أكاديمية
The Potential of JAG Ligands as Therapeutic Targets and Predictive Biomarkers in Multiple Myeloma
| العنوان: | The Potential of JAG Ligands as Therapeutic Targets and Predictive Biomarkers in Multiple Myeloma |
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| المؤلفون: | Natalia Platonova, Elisa Lazzari, Michela Colombo, Monica Falleni, Delfina Tosi, Domenica Giannandrea, Valentina Citro, Lavinia Casati, Domenica Ronchetti, Niccolò Bolli, Antonino Neri, Federica Torricelli, Leslie A. Crews, Catriona H. M. Jamieson, Raffaella Chiaramonte |
| المساهمون: | N. Platonova, E. Lazzari, M. Colombo, M. Falleni, D. Tosi, D. Giannandrea, V. Citro, L. Casati, D. Ronchetti, N. Bolli, A. Neri, F. Torricelli, L.A. Crew, C.H.M. Jamieson, R. Chiaramonte |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | JAG1, JAG2, multiple myeloma, proliferation, NOTCH signaling, mouse model, microenvironment, Settore MED/04 - Patologia Generale |
| الوصف: | The NOTCH ligands JAG1 and JAG2 have been correlated in vitro with multiple myeloma (MM) cell proliferation, drug resistance, self-renewal and a pathological crosstalk with the tumor microenvironment resulting in angiogenesis and osteoclastogenesis. These findings suggest that a therapeutic approach targeting JAG ligands might be helpful for the care of MM patients and lead us to explore the role of JAG1 and JAG2 in a MM in vivo model and primary patient samples. JAG1 and JAG2 protein expression represents a common feature in MM cell lines; therefore, we assessed their function through JAG1/2 conditional silencing in a MM xenograft model. We observed that JAG1 and JAG2 showed potential as therapeutic targets in MM, as their silencing resulted in a reduction in the tumor burden. Moreover, JAG1 and JAG2 protein expression in MM patients was positively correlated with the presence of MM cells in patients’ bone marrow biopsies. Finally, taking advantage of the Multiple Myeloma Research Foundation (MMRF) CoMMpass global dataset, we showed that JAG2 gene expression level was a predictive biomarker associated with patients’ overall survival and progression-free survival, independently from other main molecular or clinical features. Overall, these results strengthened the rationale for the development of a JAG1/2-tailored approach and the use of JAG2 as a predictive biomarker in MM. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:001086283100001; volume:24; issue:19; firstpage:1; lastpage:12; numberofpages:12; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/2434/1008690Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85174687651 |
| DOI: | 10.3390/ijms241914558 |
| الإتاحة: | https://doi.org/10.3390/ijms241914558Test https://hdl.handle.net/2434/1008690Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.1BF1B433 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms241914558 |
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