Molecular and Structural Effects of Percutaneous Interventions in Chronic Achilles Tendinopathy
| العنوان: | Molecular and Structural Effects of Percutaneous Interventions in Chronic Achilles Tendinopathy |
|---|---|
| المؤلفون: | Christelle Darrieutort-Laffite, Louis J. Soslowsky, Benoit Le Goff |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 7000, p 7000 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | ultrasound-guided injections, Percutaneous, Angiogenesis Inhibitors, Review, Bioinformatics, Achilles Tendon, Catalysis, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, In vivo, stem cells, Adrenal Cortex Hormones, medicine, Animals, Humans, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Molecular Biology, dry needling, Spectroscopy, 030222 orthopedics, Dry needling, Achilles tendinopathy, business.industry, Platelet-Rich Plasma, Organic Chemistry, Soft tissue, 030229 sport sciences, General Medicine, medicine.disease, Computer Science Applications, Tendon, Clinical trial, Disease Models, Animal, medicine.anatomical_structure, lcsh:Biology (General), lcsh:QD1-999, Platelet-rich plasma, Chronic Disease, Tendinopathy, business, Stem Cell Transplantation |
| الوصف: | Achilles tendinopathy (AT) is a common problem, especially in people of working age, as well as in the elderly. Although the pathogenesis of tendinopathy is better known, therapeutic management of AT remains challenging. Various percutaneous treatments have been applied to tendon lesions: e.g., injectable treatments, platelet-rich plasma (PRP), corticosteroids, stem cells, MMP inhibitors, and anti-angiogenic agents), as well as percutaneous procedures without any injection (percutaneous soft tissue release and dry needling). In this review, we will describe and comment on data about the molecular and structural effects of these treatments obtained in vitro and in vivo and report their efficacy in clinical trials. Local treatments have some impact on neovascularization, inflammation or tissue remodeling in animal models, but evidence from clinical trials remains too weak to establish an accurate management plan, and further studies will be necessary to evaluate their value. |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463958f51d286bc34afd0598f3abc569Test http://europepmc.org/articles/PMC7582801Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....463958f51d286bc34afd0598f3abc569 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
|---|