التفاصيل البيبلوغرافية
| العنوان: |
Platelet-Rich Plasma-Loaded Poly(D,L-lactide)-Poly(ethylene glycol)-Poly(D,L-lactide) Hydrogel Dressing Promotes Full-Thickness Skin Wound Healing in a Rodent Model. |
| المؤلفون: |
Manle Qiu, Daoyun Chen, Chaoyong Shen, Ji Shen, Huakun Zhao, Yaohua He |
| المصدر: |
International Journal of Molecular Sciences; Jul2016, Vol. 17 Issue 7, p1001, 16p, 1 Color Photograph, 1 Diagram, 7 Graphs |
| مصطلحات موضوعية: |
PLATELET-rich plasma, HYDROCOLLOID surgical dressings, SKIN wound treatment, WOUND healing, GROWTH factors, CELL-mediated cytotoxicity, CELL proliferation, THERAPEUTICS |
| مستخلص: |
Traditional therapeutic methods for skin wounds have many disadvantages, and new wound dressings that can facilitate the healing process are thus urgently needed. Platelet-rich plasma (PRP) contains multiple growth factors (GFs) and shows a significant capacity to heal soft tissue wounds. However, these GFs have a short half-life and deactivate rapidly; we therefore need a sustained delivery system to overcome this shortcoming. In this study, poly(D,L-lactide)-poly(ethylene glycol)-poly(D,L-lactide) (PDLLA-PEG-PDLLA: PLEL) hydrogel was successfully created as delivery vehicle for PRP GFs and was evaluated systematically. PLEL hydrogel was injectable at room temperature and exhibited a smart thermosensitive in situ gel-formation behavior at body temperature. In vitro cell culture showed PRP-loaded PLEL hydrogel (PRP/PLEL) had little cytotoxicity, and promoted EaHy926 proliferation, migration and tube formation; the factor release assay additionally indicated that PLEL realized the controlled release of PRP GFs for as long as 14 days. When employed to treat rodents' full-thickness skin defects, PRP/PLEL showed a significantly better ability to raise the number of both newly formed and mature blood vessels compared to the control, PLEL and PRP groups. Furthermore, the PRP/PLEL-treated group displayed faster wound closure, better reepithelialization and collagen formation. Taken together, PRP/PLEL provides a promising strategy for promoting angiogenesis and skin wound healing, which extends the potential of this dressing for clinical application. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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