Pharmacological blockade of PPAR isoforms increases conditioned fear responding in the presence of nociceptive tone
| العنوان: | Pharmacological blockade of PPAR isoforms increases conditioned fear responding in the presence of nociceptive tone |
|---|---|
| المؤلفون: | Bright N. Okine, David P. Finn, Michelle Roche, Jessica C. Gaspar, Alvaro Llorente-Berzal |
| المساهمون: | Conselho Nacional de Pesquisa (CNPq) Brazil, Science Foundation Ireland, Irish Research Council |
| المصدر: | Molecules Volume 25 Issue 4 Molecules, Vol 25, Iss 4, p 1007 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Gene Expression, Endogeny, Pharmacology, Analytical Chemistry, Extinction, Psychological, Nociceptive Pain, Rats, Sprague-Dawley, 0302 clinical medicine, Drug Discovery, Conditioning, Psychological, Medicine, fear-conditioned analgesia, Anilides, Fear conditioning, PPAR delta, Sulfones, Receptor, Oxazoles, chemistry.chemical_classification, 0303 health sciences, Fear, anxiety, 3. Good health, Nociception, Chemistry (miscellaneous), Molecular Medicine, lipids (amino acids, peptides, and proteins), PPARs, Context (language use), Thiophenes, conditioned fear, Article, nociceptive behaviour, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, Formaldehyde, Animals, PPAR alpha, Physical and Theoretical Chemistry, Freezing Reaction, Cataleptic, PPAR-beta, 030304 developmental biology, business.industry, Organic Chemistry, Antagonist, Blockade, Rats, PPAR gamma, chemistry, Tyrosine, Analgesia, business, 030217 neurology & neurosurgery |
| الوصف: | Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with three isoforms (PPAR&alpha PPAR&beta /&delta PPAR&gamma ) and can regulate pain, anxiety, and cognition. However, their role in conditioned fear and pain-fear interactions has not yet been investigated. Here, we investigated the effects of systemically administered PPAR antagonists on formalin-evoked nociceptive behaviour, fear-conditioned analgesia (FCA), and conditioned fear in the presence of nociceptive tone in rats. Twenty-three and a half hours following fear conditioning to context, male Sprague-Dawley rats received an intraplantar injection of formalin and intraperitoneal administration of vehicle, PPAR&alpha (GW6471), PPAR&beta (GSK0660) or PPAR&gamma (GW9662) antagonists, and 30 min later were re-exposed to the conditioning arena for 15 min. The PPAR antagonists did not alter nociceptive behaviour or fear-conditioned analgesia. The PPAR&alpha and PPAR&beta antagonists prolonged context-induced freezing in the presence of nociceptive tone without affecting its initial expression. The PPAR&gamma antagonist potentiated freezing over the entire trial. In conclusion, pharmacological blockade of PPAR&alpha in the presence of formalin-evoked nociceptive tone, impaired short-term, within-trial fear-extinction in rats without affecting pain response, while blockade of PPAR&gamma potentiated conditioned fear responding. These results suggest that endogenous signalling through these three PPAR isoforms may reduce the expression of conditioned fear in the presence of nociceptive tone. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2854d878180cf85a3067c7d4865a4cacTest http://hdl.handle.net/10379/16257Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2854d878180cf85a3067c7d4865a4cac |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |