دورية أكاديمية
Excellent Response to OnabotulinumtoxinA: Different Definitions, Different Predictors
| العنوان: | Excellent Response to OnabotulinumtoxinA: Different Definitions, Different Predictors |
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| المؤلفون: | Ornello, Raffaele, Baraldi, Carlo, Ahmed, Fayyaz, Negro, Andrea, Miscio, Anna Maria, Santoro, Antonio, Pozo Rosich, Patricia, Alpuente Ruiz, Alicia |
| المساهمون: | Institut Català de la Salut, Ornello R Neuroscience Section, Department of Applied Clinical Sciences and Biotechnology, University of L’Aquila, L’Aquila, Italy. Baraldi C Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, Department of Specialist Medicines, AOU Policlinico di Modena, Modena, Italy. Ahmed F Department of Neurosciences, Hull University Teaching Hospitals, Hull, UK. Negro A Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sant’Andrea Hospital, Sapienza University, Rome, Italy. Miscio AM, Santoro A Headache Center, Unit of Neurology, Fondazione IRCCS “Casa Sollievo Della Sofferenza”, San Giovanni Rotondo, Italy. Alpuente A, Pozo-Rosich P Unitat de Cefalea, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Cefalea i Dolor Neurològic, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Migranya - Tractament, Neurotoxines - Ús terapèutic, Avaluació de resultats (Assistència sanitària), DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Headache Disorders::Headache Disorders, Primary::Migraine Disorders, Other subheadings::Other subheadings::Other subheadings::/drug therapy, CHEMICALS AND DRUGS::Chemical Actions and Uses::Toxic Actions::Noxae::Neurotoxins, Other subheadings::Other subheadings::/therapeutic use, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos con cefaleas::cefaleas primarias::trastornos migrañosos, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones tóxicas::noxas::neurotoxinas, Otros calificadores::Otros calificadores::/uso terapéutico |
| الوصف: | Chronic migraine; OnabotulinumtoxinA; Predictors of response ; Migraña crónica; OnabotulinumtoxinA; Predictores de respuesta ; Migranya crònica; OnabotulinumtoxinA; Predictors de resposta ; The identification of patients who can benefit the most from the available preventive treatments is important in chronic migraine. We explored the rate of excellent responders to onabotulinumtoxinA in a multicenter European study and explored the predictors of such response, according to different definitions. A pooled analysis on chronic migraineurs treated with onabotulinumtoxinA and followed-up for, at least, 9 months was performed. Excellent responders were defined either as patients with a ≥75% decrease in monthly headache days (percent-based excellent responders) or as patients with <4 monthly headache days (frequency-based excellent responders). The characteristics of excellent responders at the baseline were compared with the ones of patients with a <30% decrease in monthly headache days. Percent-based excellent responders represented about 10% of the sample, whilst frequency-based excellent responders were about 5% of the sample. Compared with non-responders, percent-based excellent responders had a higher prevalence of medication overuse and a higher excellent response rate even after the 1st and the 2nd injection. Females were less like to be frequency-based excellent responders. Chronic migraine sufferers without medication overuse and of female sex may find fewer benefits with onabotulinumtoxinA. Additionally, the excellent response status is identifiable after the first cycle. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1660-4601 |
| العلاقة: | International Journal of Environmental Research and Public Health;19(17); https://doi.org/10.3390/ijerph191710975Test; Ornello R, Baraldi C, Ahmed F, Negro A, Miscio AM, Santoro A, et al. Excellent Response to OnabotulinumtoxinA: Different Definitions, Different Predictors. Int J Environ Res Public Health. 2022 Sep 2;19(17):10975.; https://hdl.handle.net/11351/8450Test; 000851170700001 |
| DOI: | 10.3390/ijerph191710975 |
| الإتاحة: | https://doi.org/10.3390/ijerph191710975Test https://hdl.handle.net/11351/8450Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D0C6CF1A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16604601 |
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| DOI: | 10.3390/ijerph191710975 |