Lactose Intolerance Assessed by Analysis of Genetic Polymorphism, Breath Test and Symptoms in Patients with Inflammatory Bowel Disease
| العنوان: | Lactose Intolerance Assessed by Analysis of Genetic Polymorphism, Breath Test and Symptoms in Patients with Inflammatory Bowel Disease |
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| المؤلفون: | F. Sasso, Elio Biffali, Anna Testa, Fabiana Castiglione, Francesco Manfellotto, Caterina D’Onofrio, Nicola Imperatore, Olga Maria Nardone, Alba Rocco, Roberto de Sire, Pasquale De Luca, Giovanni Annona |
| المساهمون: | Nardone, O. M., Manfellotto, F., D'Onofrio, C., Rocco, A., Annona, G., Sasso, F., De Luca, P., Imperatore, N., Testa, A., de Sire, R., Biffali, E., Castiglione, F. |
| المصدر: | Nutrients Volume 13 Issue 4 Nutrients, Vol 13, Iss 1290, p 1290 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Breath Test, medicine.medical_specialty, medicine.medical_treatment, Population, Lactose, lcsh:TX341-641, Polymorphism, Single Nucleotide, Inflammatory bowel disease, Gastroenterology, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, inflammatory bowel disease, Internal medicine, Elimination diet, Genotype, Prevalence, medicine, Humans, Prospective Studies, Genetic Testing, lactase polymorphism, education, Lactase, Breath test, Lactose intolerance, education.field_of_study, Nutrition and Dietetics, medicine.diagnostic_test, business.industry, Middle Aged, Inflammatory Bowel Diseases, medicine.disease, Prospective Studie, lactose intolerance, Breath Tests, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, business, lcsh:Nutrition. Foods and food supply, Hydrogen breath test, Human, Hydrogen, Food Science, hydrogen breath test |
| الوصف: | Many patients with inflammatory bowel disease (IBD) restrict dairy products to control their symptoms. The aim of the study was to investigate the prevalence of lactose intolerance assessed with hydrogen breath test (H-BT) in IBD patients in clinical remission compared to a sex, age and BMI matched control population. We further detected the prevalence of three single nucleotide polymorphisms of the lactase (LCT) gene: the lactase non persistence LCT-13910 CC (wildtype) and the intermediate phenotype LCT-22018 CT and LCT-13910 AG finally, we assess the correlation between genotype and H-BT. A total of 54 IBD patients and 69 control who underwent clinical evaluation, H-BT and genetic test were enrolled. H-BT was positive in 64.8% IBD patients and 62.3% control (p = 0.3). The wild-type genotype was found in 85.2% IBD patients while CT-22018, AG-13910 and CT-22018/AG-13910 polymorphisms were found in 9.3%, 1.8% and 3.7%. In the control group, the wild-type genotype, CT-22018, AG-13910 and CT-22018/AG-13910 polymorphisms were found in 87%, 5.8%, 5.8% and 1.4% of cases, respectively. Therefore, the wild-type and polymorphisms’ prevalence did not differ between IBD population and control group (85.2% vs. 87%, p = 0.1) (14.8% vs. 13%, p = 0.7). The correlation between positive H-BT and genetic analysis showed that the wild-type genotype was associated with higher rate of lactose intolerance in the total population (OR 5.31, 95%CI 1.73–16.29, p = 0.003) and in the IBD (OR 7.61, 95%CI 1.36–42.7, p = 0.02). The prevalence of lactose intolerance in IBD patients did not differ from that of control. Despite suggestive symptoms, about 1/3 of IBD patients are not lactose intolerant, thus not needing “a priori” elimination diet. This may encourage a rationale and balanced dietary management in IBD. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1508d6b25f01830609335fc701352053Test http://europepmc.org/articles/PMC8070715Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1508d6b25f01830609335fc701352053 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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