التفاصيل البيبلوغرافية
| العنوان: |
Associations of Peak-Width Skeletonized Mean Diffusivity and Post-Stroke Cognition. |
| المؤلفون: |
Jochems, Angela C. C., Muñoz Maniega, Susana, Clancy, Una, Jaime Garcia, Daniela, Arteaga, Carmen, Hewins, Will, Penman, Rachel, Hamilton, Olivia K. L., Czechoń, Agnieszka, Backhouse, Ellen V., Thrippleton, Michael J., Stringer, Michael S., Bastin, Mark. E., Valdés Hernández, Maria del C., Wiseman, Stewart, Chappell, Francesca M., Doubal, Fergus N., Wardlaw, Joanna M. |
| المصدر: |
Life (2075-1729); Sep2022, Vol. 12 Issue 9, p1362-N.PAG, 12p |
| مستخلص: |
Post-stroke cognitive impairment is common and can have major impact on life after stroke. Peak-width of Skeletonized Mean Diffusivity (PSMD) is a diffusion imaging marker of white matter microstructure and is also associated with cognition. Here, we examined associations between PSMD and post-stroke global cognition in an ongoing study of mild ischemic stroke patients. We studied cross-sectional associations between PSMD and cognition at both 3-months (N = 229) and 1-year (N = 173) post-stroke, adjusted for premorbid IQ, sex, age, stroke severity and disability, as well as the association between baseline PSMD and 1-year cognition. At baseline, (mean age = 65.9 years (SD = 11.1); 34% female), lower Montreal Cognitive Assessment (MoCA) scores were associated with older age, lower premorbid IQ and higher stroke severity, but not with PSMD (βstandardized = −0.116, 95% CI −0.241, 0.009; p = 0.069). At 1-year, premorbid IQ, older age, higher stroke severity and higher PSMD (βstandardized = −0.301, 95% CI −0.434, −0.168; p < 0.001) were associated with lower MoCA. Higher baseline PSMD was associated with lower 1-year MoCA (βstandardized = −0.182, 95% CI −0.308, −0.056; p = 0.005). PSMD becomes more associated with global cognition at 1-year post-stroke, possibly once acute effects have settled. Additionally, PSMD in the subacute phase after a mild stroke could help predict long-term cognitive impairment. [ABSTRACT FROM AUTHOR] |
|
Copyright of Life (2075-1729) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder