دورية أكاديمية
Plateletworks® as a Point-of-Care Test for ASA Non-Sensitivity
| العنوان: | Plateletworks® as a Point-of-Care Test for ASA Non-Sensitivity |
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| المؤلفون: | Hamzah Khan, Shubha Jain, Reid C. Gallant, Muzammil H. Syed, Abdelrahman Zamzam, Mohammed Al-Omran, Margaret L. Rand, Heyu Ni, Rawand Abdin, Mohammad Qadura |
| المصدر: | Journal of Personalized Medicine ; Volume 11 ; Issue 8 |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute MDPI University of Toronto MDPI AG |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | aspirin, resistance, non-sensitivity, antiplatelet, atherosclerosis, light transmission aggregometry, Plateletworks ®, psy, envir |
| الوصف: | Aspirin (ASA) therapy is proven to be effective in preventing adverse cardiovascular events ; however, up to 30% of patients are non-sensitive to their prescribed ASA dosage. In this pilot study, we demonstrated, for the first time, how ASA non-sensitivity can be diagnosed using Plateletworks®, a point-of-care platelet function test. Patients prescribed 81 mg of ASA were recruited in a series of two successive phases—a discovery phase and a validation phase. In the discovery phase, a total of 60 patients were recruited to establish a cut-off point (COP) for ASA non-sensitivity using Plateletworks®. Each sample was simultaneously cross-referenced with a light transmission aggregometer (LTA). Our findings demonstrated that > ; 52% maximal platelet aggregation using Plateletworks® had a sensitivity, specificity, and likelihood ratio of 80%, 70%, and 2.67, respectively, in predicting ASA non-sensitivity. This COP was validated in a secondary cohort of 40 patients prescribed 81 mg of ASA using Plateletworks® and LTA. Our data demonstrated that our established COP had a 91% sensitivity and 69% specificity in identifying ASA non-sensitivity using Plateletworks®. In summary, Plateletworks® is a point-of-care platelet function test that can appropriately diagnose ASA non-sensitive patients with a sensitivity exceeding 80%. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.3390/jpm11080813Test |
| DOI: | 10.3390/jpm11080813 |
| الإتاحة: | https://doi.org/10.3390/jpm11080813Test |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.2D0E5E44 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/jpm11080813 |
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