Synthesis and Biological Activities of Ethyl 2-(2-pyridylacetate) Derivatives Containing Thiourea, 1,2,4-triazole, Thiadiazole and Oxadiazole Moieties
| العنوان: | Synthesis and Biological Activities of Ethyl 2-(2-pyridylacetate) Derivatives Containing Thiourea, 1,2,4-triazole, Thiadiazole and Oxadiazole Moieties |
|---|---|
| المؤلفون: | Anna E. Koziol, David Collu, Filippo Iuliano, Piotr Tomaszewski, Michał Jóźwiak, Daniel Szulczyk, Tadeusz Lis, Marta Struga |
| المصدر: | Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Molecules; Volume 22; Issue 3; Pages: 409 Molecules, Vol 22, Iss 3, p 409 (2017) |
| بيانات النشر: | MDPI, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Models, Molecular, Pharmaceutical Science, Oxadiazole, biological activity, Microbial Sensitivity Tests, 010402 general chemistry, Ring (chemistry), Crystallography, X-Ray, 01 natural sciences, Article, Analytical Chemistry, X-ray crystal structure analysis, Cell Line, lcsh:QD241-441, chemistry.chemical_compound, Structure-Activity Relationship, 1,2,4-triazole, lcsh:Organic chemistry, Anti-Infective Agents, Drug Discovery, Thiadiazoles, 1,3,4-oxadiazole, Organic chemistry, Humans, Physical and Theoretical Chemistry, Candida albicans, Cytotoxicity, Heterocyclic derivatives, Cells, Cultured, 1,3,4-thiadiazole, Oxadiazoles, biology, Bacteria, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Fungi, Thiourea, 1,2,4-Triazole, thiourea, Triazoles, biology.organism_classification, In vitro, 0104 chemical sciences, chemistry, Chemistry (miscellaneous), HIV-1, Molecular Medicine |
| الوصف: | Thirty six novel heterocyclic derivatives of ethyl 2-(2-pyridylacetate) were efficiently synthesized. The new compounds involve the linkage of a 2-pyridyl ring with thiosemicarbazide (compounds 1–7), 1,2,4-triazole (compounds 1a–7a), 1,3,4-thiadiazole (compounds 1b–7b), and 1,3,4-oxadiazole (compounds 1f–7f) moieties. The last group of compounds 1e–7e involves the connection of a 2-pyridyl ring with 1,2,4-triazole and thiourea. 1H-NMR, 13C-NMR and MS methods were used to confirm the structures of the obtained derivatives. The molecular structures of 3, 3b, 7a and 7f were further confirmed by X-ray crystallography. All obtained compounds were tested in vitro against a number of microorganisms, including Gram-positive cocci, Gram-negative rods and Candida albicans. In addition, the obtained compounds were tested for cytotoxicity and antiviral activity against HIV-1. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f7b65a32faf0720e27b39f0a9d03caTest http://europepmc.org/articles/PMC6155191Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....12f7b65a32faf0720e27b39f0a9d03ca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
|---|