Protective Effects of Quercetin and Quercetin-5',8-Disulfonate against Carbon Tetrachloride-Caused Oxidative Liver Injury in Mice
| العنوان: | Protective Effects of Quercetin and Quercetin-5',8-Disulfonate against Carbon Tetrachloride-Caused Oxidative Liver Injury in Mice |
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| المؤلفون: | Yanmang Cui, Yong Han, Xingbin Yang, Yanfei Sun, Yan Zhao |
| المصدر: | Molecules Molecules; Volume 19; Issue 1; Pages: 291-305 Molecules, Vol 19, Iss 1, Pp 291-305 (2013) |
| بيانات النشر: | MDPI, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Antioxidant, medicine.medical_treatment, Pharmaceutical Science, Pharmacology, medicine.disease_cause, Antioxidants, Analytical Chemistry, quercetin, chemistry.chemical_compound, Mice, hepatoprotective effects, quercetin-5',8-disulfonate, Malondialdehyde, Drug Discovery, heterocyclic compounds, Carbon Tetrachloride, chemistry.chemical_classification, Liver injury, biology, Molecular Structure, Chemistry, Glutathione peroxidase, Alanine Transaminase, Biochemistry, Chemistry (miscellaneous), Molecular Medicine, HPLC, absorption, Chemical and Drug Induced Liver Injury, Quercetin, Hydrophobic and Hydrophilic Interactions, Article, lcsh:QD241-441, Superoxide dismutase, lcsh:Organic chemistry, medicine, Animals, Aspartate Aminotransferases, Physical and Theoretical Chemistry, Glutathione Peroxidase, L-Lactate Dehydrogenase, Superoxide Dismutase, Organic Chemistry, medicine.disease, Oxidative Stress, Hepatoprotection, biology.protein, Oxidative stress |
| الوصف: | Oxidative stress is one of the major factors in the pathogenesis of liver disease. Quercetin is a plant-based antioxidant traditionally used as a treatment for hepatic injury, but its poor solubility affects its bioavailability. We here report the regulative effects on hepatoprotection and absorption in mice of quercetin sulfation to form quercetin-5',8-disulfonate (QS), a novel synthetic compound. Oral administration of both QS and the parent quercetin at 100, 200 and 500 mg/kg·bw prior to acute CCl4 oxidative damage in mice, effectively attenuated serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities and hepatic malondialdehyde (MDA) levels (p < 0.05), and suppressed the CCl4-induced depletion of glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD). Selective 5',8-sulfation of quercetin increased the hepatoprotective effect, and its relative absorption relative to quercetin (p < 0.05) as indicated by an improved 24-hour urinary excretion and a decreased fecal excretion determined by HPLC. These results and histopathological observations collectively demonstrate that quercetin sulfation increases its hepatoprotective effects and absorption in mice, and QS has potential as a chemopreventive and chemotherapeutic agent for liver diseases. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dddfb9a895c7021e296f53e871021fTest http://europepmc.org/articles/PMC6271165Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....75dddfb9a895c7021e296f53e871021f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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