Glycine Receptors in Spinal Nociceptive Control—An Update
| العنوان: | Glycine Receptors in Spinal Nociceptive Control—An Update |
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| المؤلفون: | Karolina Werynska, Gonzalo E. Yévenes, Hanns Ulrich Zeilhofer, Jacinthe Gingras |
| المصدر: | Biomolecules Biomolecules, Vol 11, Iss 846, p 846 (2021) Biomolecules, 11 (6) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Nociception, 0301 basic medicine, Spinal Cord Dorsal Horn, glycine, GABA, pain, inhibition, spinal cord, dorsal horn, hyperalgesia, allodynia, circuit, mouse, Hindbrain, Review, Microbiology, Biochemistry, Protein Structure, Secondary, 03 medical and health sciences, Receptors, Glycine, 0302 clinical medicine, medicine, Animals, Humans, Propofol, Molecular Biology, Glycine receptor, business.industry, Drug discovery, Chronic pain, medicine.disease, Spinal cord, QR1-502, 3. Good health, 030104 developmental biology, Allodynia, medicine.anatomical_structure, Zonisamide, Hyperalgesia, medicine.symptom, business, Neuroscience, 030217 neurology & neurosurgery, Endocannabinoids |
| الوصف: | Diminished inhibitory control of spinal nociception is one of the major culprits of chronic pain states. Restoring proper synaptic inhibition is a well-established rational therapeutic approach explored by several pharmaceutical companies. A particular challenge arises from the need for site-specific intervention to avoid deleterious side effects such as sedation, addiction, or impaired motor control, which would arise from wide-range facilitation of inhibition. Specific targeting of glycinergic inhibition, which dominates in the spinal cord and parts of the hindbrain, may help reduce these side effects. Selective targeting of the α3 subtype of glycine receptors (GlyRs), which is highly enriched in the superficial layers of the spinal dorsal horn, a key site of nociceptive processing, may help to further narrow down pharmacological intervention on the nociceptive system and increase tolerability. This review provides an update on the physiological properties and functions of α3 subtype GlyRs and on the present state of related drug discovery programs. |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| تدمد: | 2218-273X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76841fa18b1c0bfeffdf42dcf300c7cTest http://europepmc.org/articles/PMC8228028Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e76841fa18b1c0bfeffdf42dcf300c7c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2218273X |
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