Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence
| العنوان: | Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence |
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| المؤلفون: | Joshua Sutherland, Elina Hyppönen, Ang Zhou, Liana Najjar |
| المساهمون: | Najjar, Liana, Sutherland, Joshua, Zhou, Ang, Hyppönen, Elina |
| المصدر: | Nutrients Nutrients, Vol 13, Iss 4260, p 4260 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, single nucleotide, Male, Vesicular Transport Proteins, vitamin D, polymorphism, Cohort Studies, chemistry.chemical_compound, Polymorphism (computer science), TX341-641, Child, Vitamin D3 24-Hydroxylase, Nutrition and Dietetics, Vitamin D-Binding Protein, 25-hydroxyvitamin D, type 1, Meta-analysis, Child, Preschool, diabetes mellitus, Cholestanetriol 26-Monooxygenase, Female, Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor, Cohort study, Vitamin, Adult, medicine.medical_specialty, Oxidoreductases Acting on CH-CH Group Donors, Adolescent, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Amidohydrolases, Young Adult, Internal medicine, Diabetes mellitus, medicine, Vitamin D and neurology, Humans, Genetic Predisposition to Disease, Cytochrome P450 Family 2, Type 1 diabetes, Nutrition. Foods and food supply, business.industry, medicine.disease, Vitamin D Deficiency, meta-analysis, Diabetes Mellitus, Type 1, chemistry, CYP2R1, Receptors, Calcitriol, Systematic Review, business, Food Science |
| الوصف: | Several observational studies have examined vitamin D pathway polymorphisms and their association with type 1 diabetes (T1D) susceptibility, with inconclusive results. We aimed to perform a systematic review and meta-analysis assessing associations between selected variants affecting 25-hydroxyvitamin D [25(OH)D] and T1D risk. We conducted a systematic search of Medline, Embase, Web of Science and OpenGWAS updated in April 2021. The following keywords “vitamin D” and/or “single nucleotide polymorphisms (SNPs)” and “T1D” were selected to identify relevant articles. Seven SNPs (or their proxies) in six genes were analysed: CYP2R1 rs10741657, CYP2R1 (low frequency) rs117913124, DHCR7/NADSYN1 rs12785878, GC rs3755967, CYP24A1 rs17216707, AMDHD1 rs10745742 and SEC23A rs8018720. Seven case-control and three cohort studies were eligible for quantitative synthesis (n = 10). Meta-analysis results suggested no association with T1D (range of pooled ORs for all SNPs: 0.97–1.02; p > 0.01). Heterogeneity was found in DHCR7/NADSYN1 rs12785878 (I2: 64.8%, p = 0.02). Sensitivity analysis showed exclusion of any single study did not alter the overall pooled effect. No association with T1D was observed among a Caucasian subgroup. In conclusion, the evidence from the meta-analysis indicates a null association between selected variants affecting serum 25(OH)D concentrations and T1D. |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b870821afe14962009571c35747999fTest http://europepmc.org/articles/PMC8707565Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1b870821afe14962009571c35747999f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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