Assessment of Inner Retinal Layers and Choroidal Thickness in Type 1 Diabetes Mellitus: A Cross-Sectional Study
| العنوان: | Assessment of Inner Retinal Layers and Choroidal Thickness in Type 1 Diabetes Mellitus: A Cross-Sectional Study |
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| المؤلفون: | Esmeralda Castelblanco, Rafael Simó, Xavier Valldeperas, Cristina Hernández, Carme Jurjo, Alicia Traveset, Anna Ramírez-Morros, Didac Mauricio, M. Carbonell, Jordi Real, Núria Alonso |
| المساهمون: | Institut Català de la Salut, [Carbonell M] Department of Ophthalmology, University Hospital Germans Trias i Pujol, Badalona, Spain. Department of Surgery, Barcelona Autonomous University (UAB), Barcelona, Spain. [Alonso N] Department of Endocrinology and Nutrition, University Hospital and Health Science Research Institute Germans Trias i Pujol, Badalona, Spain. Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, Spain. Department of Medicine, Barcelona Autonomous University (UAB), Barcelona, Spain. [Castelblanco E] Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, Spain. Department of Endocrinology & Nutrition, Hospital de la Santa Creu i Sant Pau & Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, Spain. DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. [Real J] Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, Spain. DAP-Cat Group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. [Ramírez-Morros A] Department of Endocrinology and Nutrition, University Hospital and Health Science Research Institute Germans Trias i Pujol, Badalona, Spain. [Simó R, Hernández C] ] Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, Spain. Servei d’Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de recerca en Diabetis i Metabolisme, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Journal of Clinical Medicine, Vol 8, Iss 9, p 1412 (2019) Journal of Clinical Medicine Volume 8 Issue 9 r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Repositorio Abierto de la UdL Universitad de Lleida Scientia r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol Recercat. Dipósit de la Recerca de Catalunya |
| بيانات النشر: | MDPI, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | choroidal thickness, Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Angiopathies::Diabetic Retinopathy [DISEASES], estimated glomerular filtration rate, endocrine system diseases, Cross-sectional study, type 1 diabetes, lcsh:Medicine, Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cross-Sectional Studies [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], retinal ganglion cell layer, low density lipoprotein cholesterol, chemistry.chemical_compound, 0302 clinical medicine, high density lipoprotein cholesterol, Diabetic retinopathy, glucose, hemoglobin A1c, ganglion cell layer, Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 1 [DISEASES], adult, creatinine, General Medicine, Control subjects, laser coagulation, retinal nerve fibre layer, técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios transversales [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], diabetic retinopathy, female, spectral domain optical coherence tomography, medicine.anatomical_structure, Type 1 diabetes, triacylglycerol, enfermedades del sistema endocrino::diabetes mellitus::complicaciones de la diabetes::angiopatías diabéticas::retinopatía diabética [ENFERMEDADES], medicine.medical_specialty, Ganglion cell layer, hypertension, enfermedades del sistema endocrino::diabetes mellitus::diabetes mellitus tipo I [ENFERMEDADES], retinal nerve fiber layer thickness, 030209 endocrinology & metabolism, insulin dependent diabetes mellitus, Article, 03 medical and health sciences, male, Ophthalmology, medicine, cross-sectional study, controlled study, human, myopia, albumin, Diabetis - Investigació, Retina, macular edema, business.industry, Choroid, dyslipidemia, lcsh:R, Retinal, Retinal nerve fibre layer, medicine.disease, major clinical study, body mass, glaucoma, chemistry, eye inflammation, Retinopatia diabètica, 030221 ophthalmology & optometry, sense organs, Bruch membrane, business, choroid |
| الوصف: | Recent studies have shown that retinal neurodegeneration may precede visible vascular changes in diabetic retinopathy (DR). In addition, the relationship of choroidal thickness (CT) with DR stage is not well defined. To assess the inner retinal and choroidal structural changes in type 1 diabetic subjects (T1D), a cross-sectional study was conducted in 242 T1D patients and in 69 age-matched, non-diabetic individuals. The nasal retinal nerve fibre layer (RNFL) thickness was lower in T1D patients without DR (p < 0.001), with mild DR (p < 0.001), and with advanced DR (p < 0.001) compared to control subjects. The ganglion cell layer (GCL) thickness was lower in T1D patients with advanced DR compared to those with mild DR (p = 0.003) and without DR (p < 0.001) and compared to the control subjects (p < 0.001). T1D subjects with no DR and mild DR had higher CT than the control subjects, but the CT in T1D patients with advanced DR was lower (p = 0.038) than that in T1D subjects with mild DR and was not significantly different from that of the control subjects. In conclusion, T1D subjects showed a significant thinning of the nasal RNFL in the early stages of the disease, even before any vascular changes in the retina. A decrease in the GCL thickness during advanced DR stages was observed. Choroidal thickness was higher in T1D subjects without DR and in early DR stages but decreased in advanced stages. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8111db0dc41389cf3116b9b2817cc2acTest https://hdl.handle.net/10459.1/68231Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8111db0dc41389cf3116b9b2817cc2ac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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