Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes
| العنوان: | Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes |
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| المؤلفون: | David A. Baidal, Virginia Fuenmayor, Ana Alvarez, Camillo Ricordi, Carmen Chavez, Andrea Fabbri, Rodolfo Alejandro, Marco Infante, Michael J. Clare-Salzler, Nathalia Padilla, Janine Sanchez, Massimiliano Caprio |
| المصدر: | Nutrients Nutrients, Vol 11, Iss 9, p 2185 (2019) |
| بيانات النشر: | MDPI, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, calcitriol, Male, endocrine system diseases, type 1 diabetes, vitamin D, Autoimmunity, Review, medicine.disease_cause, chemistry.chemical_compound, Settore MED/13, 0302 clinical medicine, Risk Factors, Insulin-Secreting Cells, Child, honeymoon phase, Nutrition and Dietetics, Alfacalcidol, Middle Aged, calcidiol, alfacalcidol, Female, immunotherapy, lcsh:Nutrition. Foods and food supply, Type 1, cholecalciferol, Adult, Adolescent, lcsh:TX341-641, 030209 endocrinology & metabolism, vitamin D deficiency, 03 medical and health sciences, Diabetes Mellitus, medicine, Genetic predisposition, Vitamin D and neurology, Animals, Humans, Immunologic Factors, Autoimmune disease, Type 1 diabetes, business.industry, medicine.disease, Vitamin D Deficiency, 030104 developmental biology, Diabetes Mellitus, Type 1, chemistry, T1D, autoimmunity, Vitamin D, Immunology, Cholecalciferol, business, Food Science |
| الوصف: | Type 1 diabetes (T1D) is a chronic autoimmune disease leading to immune-mediated destruction of pancreatic beta cells, resulting in the need for insulin therapy. The incidence of T1D is increasing worldwide, thus prompting researchers to investigate novel immunomodulatory strategies to halt autoimmunity and modify disease progression. T1D is considered as a multifactorial disease, in which genetic predisposition and environmental factors interact to promote the triggering of autoimmune responses against beta cells. Over the last decades, it has become clear that vitamin D exerts anti-inflammatory and immunomodulatory effects, apart from its well-established role in the regulation of calcium homeostasis and bone metabolism. Importantly, the global incidence of vitamin D deficiency is also dramatically increasing and epidemiologic evidence suggests an involvement of vitamin D deficiency in T1D pathogenesis. Polymorphisms in genes critical for vitamin D metabolism have also been shown to modulate the risk of T1D. Moreover, several studies have investigated the role of vitamin D (in different doses and formulations) as a potential adjuvant immunomodulatory therapy in patients with new-onset and established T1D. This review aims to present the current knowledge on the immunomodulatory effects of vitamin D and summarize the clinical interventional studies investigating its use for prevention or treatment of T1D. |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae90f41c37b13ab7c50d276ba00661cTest http://europepmc.org/articles/PMC6769474Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cae90f41c37b13ab7c50d276ba00661c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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