Assessing mPTC Progression during Active Surveillance: Volume or Diameter Increase?
| العنوان: | Assessing mPTC Progression during Active Surveillance: Volume or Diameter Increase? |
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| المؤلفون: | Eleonora Molinaro, Maria Cristina Campopiano, Rossella Elisei, Teresa Rago, Paolo Piaggi, Alessandro Prete, Laura Agate, M Scutari, Antonio Matrone |
| المصدر: | Journal of Clinical Medicine Volume 10 Issue 18 Journal of Clinical Medicine, Vol 10, Iss 4068, p 4068 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, observation, Tumor size, business.industry, Disease progression, active surveillance, Papillary Thyroid Microcarcinoma, Urology, differentiated thyroid cancer, General Medicine, Volume change, papillary thyroid microcarcinoma, management, tailored treatment for thyroid cancer, Article, Volume (thermodynamics), Medicine, business |
| الوصف: | Active surveillance (AS) is considered an alternative to immediate surgery in micropapillary thyroid carcinoma (mPTC). However, the definition of clinical mPTC progression during AS is controversial. We evaluated changes in tumor size using both tumor diameters and volume in 109 patients with mPTC followed in an AS protocol for a mean period of 31 ± 18 months. At the time of data lock, 19/109 (17.4%) mPTC reached and maintained a volume increase of ≥50%. However, only 3/19 (15.7%) showed progression, according to the diameter increase. The remaining 16 showed a slight diameter growth without reaching the original protocol progression criteria. The mean mPTC growth rate in stable cases was 0.37 mm3/month, while it was significantly greater in the mPTC, which achieved a volume change ≥50% with respect to the other. The two mPTC that developed a significant diameter increase had a growth rate of 41 and 18 mm3/month. Instead, the growth rates of the three mPTC that developed lymph node metastases were 0, 2.5 and 16 mm3/month. The ≥50% volume increase appears to be a too sensitive marker of disease progression, with a downstream higher surgery rate. The assessment of growth rate could distinguish mPTC with high and low growth rates, which would allow us to tailor the algorithm of the evaluations to a more appropriate timing. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2077-0383 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd51fde30a13cd23deacade1e720f063Test http://europepmc.org/articles/PMC8471696Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cd51fde30a13cd23deacade1e720f063 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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