Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study
| العنوان: | Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study |
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| المؤلفون: | Paulo A. Lotufo, Dirce Maria Lobo Marchioni, Bartira Mendes Gorgulho, Gustavo Rosa Gentil Andrade, Isabela M. Benseñor |
| المصدر: | Nutrients Nutrients, Vol 10, Iss 6, p 693 (2018) Volume 10 Issue 6 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | MDPI, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Longitudinal study, endocrine system diseases, Cross-sectional study, Prohormone, Thyroid Gland, Physiology, Thyrotropin, thyroid, Cohort Studies, 0302 clinical medicine, adults, Prevalence, Longitudinal Studies, Subclinical infection, Nutrition and Dietetics, Thyroid disease, ESTUDOS TRANSVERSAIS, Middle Aged, Nutrition Surveys, subclinical hypothyroidism, Workforce, 0305 other medical science, lcsh:Nutrition. Foods and food supply, Brazil, medicine.drug, Adult, endocrine system, Universities, Nutritional Status, 030209 endocrinology & metabolism, lcsh:TX341-641, Article, 03 medical and health sciences, Selenium, Hypothyroidism, medicine, Humans, Aged, 030505 public health, business.industry, Odds ratio, medicine.disease, Confidence interval, Diet, Thyroxine, Cross-Sectional Studies, Asymptomatic Diseases, Dietary Supplements, business, Deficiency Diseases, Food Science, Hormone |
| الوصف: | Selenium (Se) participates in several enzymatic reactions necessary for regulating the homeostasis of thyroid hormones. We aimed to analyze the association between dietary Se intake and subclinical hypothyroidism. Baseline data from the Longitudinal Study of Adult Health (Estudo Longitudinal de Saú de do Adulto&mdash ELSA-Brasil) in Brazil were analyzed, with a final sample size of 14,283 employees of both sexes aged 35&ndash 74 years. Dietary data was collected using a previously validated food frequency questionnaire. Subclinical hypothyroidism was categorized as thyroid-stimulating hormone levels of > 4.0 IU/mL and free prohormone thyroxine levels within normal limits, without administering drugs for thyroid disease. A multiple logistic regression model was used to assess the relationship between the presence of subclinical hypothyroidism and tertiles of Se consumption. The prevalence of subclinical hypothyroidism in the study sample was 5.4% (95% confidence interval [CI], 3.8&ndash 7.0%). Compared with the first tertile of Se intake, the second (odds ratio [OR], 0.79 95% CI, 0.65&ndash 0.96%) and third (OR, 0.72 95% CI, 0.58&ndash 0.90%) tertiles were inversely associated with subclinical hypothyroidism, however further research is needed to confirm the involvement of Se in subclinical hypothyroidism using more accurate methodologies of dietary assessment and nutritional status to evaluate this relationship. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f458e3d8688d522e37e52b1371a08eTest http://europepmc.org/articles/PMC6024881Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....18f458e3d8688d522e37e52b1371a08e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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