نتائج البحث

1

Fluorescence Cross-Correlation Spectroscopy Yields True Affinity and Binding Kinetics of Plasmodium Lactate Transport Inhibitors

المؤلفون: Iga Jakobowska, Stefan Hannus, Björn Henke, Stefano Minguzzi, Nathan Hugo Epalle, Frank Becker, Eric Beitz, Kerrin Hansen

المساهمون: Iga Jakobowska, Frank Becker, Stefano Minguzzi, Kerrin Hansen, Björn Henke, Nathan Hugo Epalle, Eric Beitz, Stefan Hannus

المصدر: Pharmaceuticals
Volume 14
Issue 8
Pharmaceuticals, Vol 14, Iss 757, p 757 (2021)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f232c0a8a9f7f3eb1b2229a4791f29Test
http://europepmc.org/articles/PMC8399565Test

2

Effect of humanizing mutations on the stability of the llama single-domain variable region

المؤلفون: Miguel A. Soler, Sara Fortuna, Jiewen Wang, Gregor Bajc, Sandra Folarin Oloketuyi, Ario de Marco, Barbara Medagli, He Huang

المساهمون: Soler, Miguel A., Medagli, Barbara, Wang, Jiewen, Oloketuyi, Sandra, Bajc, Gregor, Huang, He, Fortuna, Sara, Marco, Ario de

المصدر: Biomolecules, vol. 11, no. 2, 163, 2021.
Biomolecules
Volume 11
Issue 2
Biomolecules, Vol 11, Iss 163, p 163 (2021)

مصطلحات موضوعية: Models, Molecular, In silico, Mutant, lcsh:QR1-502, Heterologous, Enzyme-Linked Immunosorbent Assay, Sequence (biology), Computational biology, Molecular Dynamics Simulation, Biochemistry, lcsh:Microbiology, Article, 03 medical and health sciences, nanobody humanization, Molecular level, Nanobody humanization, Nanobody framework, udc:577, Animals, Cluster Analysis, Humans, Cloning, Molecular, Molecular Biology, CDR grafting, Modeling, Gene Library, 030304 developmental biology, 0303 health sciences, Chemistry, nanobody framework, modeling, 030302 biochemistry & molecular biology, Single-Domain Antibodies, Surface Plasmon Resonance, Antigen binding, Transformation (genetics), Solubility, Mutation, Primary sequence, Camelids, New World, Protein Binding

وصف الملف: application/pdf; text/url; ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f1cb72bd5bf6e29f070b7e6887c8c4Test
https://repozitorij.uni-lj.si/Dokument.php?id=153621&dnTest=

3

Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae

المؤلفون: Josphat C. Matasyoh, Johannes L. Vrijdag, Joris Winderickx, Geert Callewaert, Elja Eskes, Patrick Van Dijck, Liesbeth Demuyser, Petra D'hooge, Walter Luyten, Purity N. Kipanga

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5756, p 5756 (2021)
Volume 22
Issue 11

مصطلحات موضوعية: 0301 basic medicine, Antifungal Agents, Mutant, V-ATPase, chemistry.chemical_compound, 0302 clinical medicine, Ca2+ signaling and Ca2+ homeostasis, Homeostasis, Biology (General), Spectroscopy, biology, General Medicine, Hydrogen-Ion Concentration, Computer Science Applications, Cell biology, Mitochondria, Nucleosomes, Chemistry, Vacuolar acidification, TORC1 signaling, Nucleosome mobilization, Sesquiterpenes, Signal Transduction, Vacuolar Proton-Translocating ATPases, Saccharomyces cerevisiae Proteins, QH301-705.5, Saccharomyces cerevisiae, Polygodial, Microbial Sensitivity Tests, Mechanistic Target of Rapamycin Complex 1, Catalysis, Article, Inorganic Chemistry, Mitochondrial Proteins, 03 medical and health sciences, Ribosomal protein, Drug Resistance, Fungal, ubiquitin, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, haploid deletion mutant library, Organic Chemistry, Autophagy, biology.organism_classification, 030104 developmental biology, chemistry, Calcium, vacuolar pH, 030217 neurology & neurosurgery, antifungal

وصف الملف: Electronic; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da98ac47f868b157e818844c0feccb5cTest
https://lirias.kuleuven.be/handle/123456789/676156Test

4

Cancer Cells Shuttle Extracellular Vesicles Containing Oncogenic Mutant p53 Proteins to the Tumor Microenvironment

المؤلفون: Bibek Bhatta, Ishai Luz, Christian Krueger, David P. Lane, Fanny Xueting Teo, Tomer Cooks, Kanaga Sabapathy

المصدر: Cancers
Cancers, Vol 13, Iss 2985, p 2985 (2021)
Volume 13
Issue 12

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e3de266a6b2b2e66fffdf36606b403Test
http://europepmc.org/articles/PMC8232660Test

5

Brown Spiders’ Phospholipases-D with Potential Therapeutic Applications: Functional Assessment of Mutant Isoforms

المؤلفون: Andrea Senff-Ribeiro, Larissa Vuitika, Thaís Pereira da Silva, Fernando Jacomini de Castro, Silvio Sanches Veiga, Nayanne Louise Costacurta Polli, Raghuvir K. Arni, Marianna Boia-Ferreira, Bruno Cesar Antunes, João Carlos Minozzo, Fernando Hitomi Matsubara, Ricardo Barros Mariutti, Luiza Helena Gremski, Ana Carolina Martins Wille

المساهمون: Universidade Federal do Paraná (UFPR), Centro de Produção e Pesquisa de Imunobiológicos (CPPI), Universidade Estadual Paulista (Unesp), Universidade Estadual de Ponta Grossa (UEPG)

المصدر: Biomedicines
Volume 9
Issue 3
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Biomedicines, Vol 9, Iss 320, p 320 (2021)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bd0128bce0c6d2880a4ae2a3f05c61Test
http://europepmc.org/articles/PMC8004160Test

6

Semi-Synthesis of Small Molecules of Aminocarbazoles: Tumor Growth Inhibition and Potential Impact on p53

المؤلفون: Solida Long, Luís Gales, Carla Carvalho, Lucília Saraiva, Emília Sousa, Ploenthip Puthongking, Joana B. Loureiro, Madalena Pinto

المساهمون: Universidade do Minho, Instituto de Investigação e Inovação em Saúde

المصدر: Molecules
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Volume 26
Issue 6
Molecules, Vol 26, Iss 1637, p 1637 (2021)

مصطلحات موضوعية: p53, Mutant, Pharmaceutical Science, aminocarbazoles, medicine.disease_cause, Reductive amination, Analytical Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Neoplasms, Drug Discovery, 0303 health sciences, Mutation, Tumor, Small molecule, 3. Good health, Biochemistry, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Molecular Medicine, Growth inhibition, HT29 Cells, tumor, Aminocarbazoles, Carbazoles, Antineoplastic Agents, alkaloids, Article, Cell Line, lcsh:QD241-441, Small Molecule Libraries, 03 medical and health sciences, Alkaloids, lcsh:Organic chemistry, Cell Line, Tumor, medicine, Humans, mutant, Physical and Theoretical Chemistry, 030304 developmental biology, Carbazole, Organic Chemistry, Clausena, Heptaphylline, heptaphylline, HCT116 Cells, Yeast, chemistry, Cell culture, Tumor Suppressor Protein p53

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325cecbbec3e91a8230472ef82f44219Test
http://europepmc.org/articles/PMC7998292Test

7

Fatal Attraction: The Case of Toxic Soluble Dimers of Truncated PQBP-1 Mutants in X-Linked Intellectual Disability

المؤلفون: Yu Wai Chen, Shah Kamranur Rahman

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 2240, p 2240 (2021)

مصطلحات موضوعية: 0301 basic medicine, X-linked intellectual disability, Protein Conformation, Mutant, IDP, Review, Protein aggregation, Oligomer, lcsh:Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Genes, X-Linked, Frameshift Mutation, lcsh:QH301-705.5, Spectroscopy, biology, Chemistry, aggregation, General Medicine, Renpenning syndrome, Computer Science Applications, DNA-Binding Proteins, Biochemistry, RNA splicing, RNA Splicing, Intrinsically disordered proteins, Catalysis, Inorganic Chemistry, WW domain, 03 medical and health sciences, oligomerisation, Intellectual Disability, medicine, Humans, Physical and Theoretical Chemistry, Molecular Biology, XLID, Organic Chemistry, medicine.disease, intrinsically disordered protein, misfolding, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, biology.protein, dimerisation, Mutant Proteins, Fatal attraction, Protein Multimerization, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef1e3306de9bc1fae772f48bd3c359aTest
http://europepmc.org/articles/PMC7956452Test

8

A Candida parapsilosis Overexpression Collection Reveals Genes Required for Pathogenesis

المؤلفون: Tibor Németh, Csaba Vágvölgyi, Attila Gácser, Joshua D. Nosanchuk, Renáta Tóth, Sára Eszter Pál

المصدر: Journal of Fungi
Volume 7
Issue 2
Journal of Fungi, Vol 7, Iss 97, p 97 (2021)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690ed3c3092ca902cd35bd548d9c3f62Test
http://europepmc.org/articles/PMC7911391Test

9

Characterization of the Frmd7 Knock-Out Mice Generated by the EUCOMM/COMP Repository as a Model for Idiopathic Infantile Nystagmus (IIN)

المؤلفون: Diego Gomez-Nicola, Tutte Newall, Jay E. Self, Andrew J. Lotery, Ahmed Salman, Jennifer Scott, Helen Griffiths, Helena Lee, Samuel B. Hutton

المصدر: Genes
Volume 11
Issue 10
Genes, Vol 11, Iss 1157, p 1157 (2020)

مصطلحات موضوعية: Male, 0301 basic medicine, retina, lcsh:QH426-470, optokinetic nystagmus, Mutant, Gene Expression, Nystagmus, Biology, Article, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Electroretinography, Genetics, medicine, Animals, Nystagmus, Optokinetic, Alleles, Genetics (clinical), Mice, Knockout, Retina, FRMD7, Genetic Diseases, X-Linked, Retinal, Idiopathic Infantile Nystagmus, Optokinetic reflex, lcsh:Genetics, Cytoskeletal Proteins, Disease Models, Animal, Electrophysiology, Amacrine Cells, 030104 developmental biology, medicine.anatomical_structure, chemistry, Mutation, Knockout mouse, 030221 ophthalmology & optometry, Reflex, Female, medicine.symptom, Nystagmus, Congenital, Neuroscience, Tomography, Optical Coherence, nystagmus

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c730c83c63ad874cb4e2fe608c56617Test
https://ora.ox.ac.uk/objects/uuid:70c72494-580e-4ea6-b160-c08a85dd5c4dTest

10

ZFP36L2 Role in Thyroid Functionality

المؤلفون: Francesco Albano, Marco Colella, Concetta Ambrosino, Valeria Tucci, Luca Roberto, Filomena Russo, Immacolata Porreca, Mario De Felice, Massimo Mallardo, Pina Marotta, Perry J. Blackshear, Carla Reale

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9379, p 9379 (2021)
Volume 22
Issue 17

مصطلحات موضوعية: endocrine system diseases, Thyroid Gland, Thyrotropin, Notch1, 0302 clinical medicine, Gene expression, Transcriptional regulation, Biology (General), Receptor, Notch1, Spectroscopy, Regulation of gene expression, 0303 health sciences, Triiodothyronine, Thyroid, apoptosis, General Medicine, Computer Science Applications, Chemistry, medicine.anatomical_structure, Female, medicine.medical_specialty, endocrine system, Zfp36l2 KO, QH301-705.5, Cell Survival, 030209 endocrinology & metabolism, Biology, Catalysis, Article, Cell Line, Inorganic Chemistry, 03 medical and health sciences, PAX8 Transcription Factor, Tristetraprolin, In vivo, Internal medicine, medicine, Nis, Animals, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, 030304 developmental biology, Organic Chemistry, RNA stability, Mice, Mutant Strains, Rats, Mice, Inbred C57BL, Endocrinology, Gene Expression Regulation, hypothyroidism, PAX8, Gene Deletion, Hormone

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00254b463295726a2b636e9ac2a31fe3Test
http://europepmc.org/articles/PMC8431063Test

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