نتائج البحث

1

Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae

المؤلفون: Josphat C. Matasyoh, Johannes L. Vrijdag, Joris Winderickx, Geert Callewaert, Elja Eskes, Patrick Van Dijck, Liesbeth Demuyser, Petra D'hooge, Walter Luyten, Purity N. Kipanga

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5756, p 5756 (2021)
Volume 22
Issue 11

مصطلحات موضوعية: 0301 basic medicine, Antifungal Agents, Mutant, V-ATPase, chemistry.chemical_compound, 0302 clinical medicine, Ca2+ signaling and Ca2+ homeostasis, Homeostasis, Biology (General), Spectroscopy, biology, General Medicine, Hydrogen-Ion Concentration, Computer Science Applications, Cell biology, Mitochondria, Nucleosomes, Chemistry, Vacuolar acidification, TORC1 signaling, Nucleosome mobilization, Sesquiterpenes, Signal Transduction, Vacuolar Proton-Translocating ATPases, Saccharomyces cerevisiae Proteins, QH301-705.5, Saccharomyces cerevisiae, Polygodial, Microbial Sensitivity Tests, Mechanistic Target of Rapamycin Complex 1, Catalysis, Article, Inorganic Chemistry, Mitochondrial Proteins, 03 medical and health sciences, Ribosomal protein, Drug Resistance, Fungal, ubiquitin, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, haploid deletion mutant library, Organic Chemistry, Autophagy, biology.organism_classification, 030104 developmental biology, chemistry, Calcium, vacuolar pH, 030217 neurology & neurosurgery, antifungal

وصف الملف: Electronic; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da98ac47f868b157e818844c0feccb5cTest
https://lirias.kuleuven.be/handle/123456789/676156Test

2

Semi-Synthesis of Small Molecules of Aminocarbazoles: Tumor Growth Inhibition and Potential Impact on p53

المؤلفون: Solida Long, Luís Gales, Carla Carvalho, Lucília Saraiva, Emília Sousa, Ploenthip Puthongking, Joana B. Loureiro, Madalena Pinto

المساهمون: Universidade do Minho, Instituto de Investigação e Inovação em Saúde

المصدر: Molecules
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Volume 26
Issue 6
Molecules, Vol 26, Iss 1637, p 1637 (2021)

مصطلحات موضوعية: p53, Mutant, Pharmaceutical Science, aminocarbazoles, medicine.disease_cause, Reductive amination, Analytical Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Neoplasms, Drug Discovery, 0303 health sciences, Mutation, Tumor, Small molecule, 3. Good health, Biochemistry, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Molecular Medicine, Growth inhibition, HT29 Cells, tumor, Aminocarbazoles, Carbazoles, Antineoplastic Agents, alkaloids, Article, Cell Line, lcsh:QD241-441, Small Molecule Libraries, 03 medical and health sciences, Alkaloids, lcsh:Organic chemistry, Cell Line, Tumor, medicine, Humans, mutant, Physical and Theoretical Chemistry, 030304 developmental biology, Carbazole, Organic Chemistry, Clausena, Heptaphylline, heptaphylline, HCT116 Cells, Yeast, chemistry, Cell culture, Tumor Suppressor Protein p53

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325cecbbec3e91a8230472ef82f44219Test
http://europepmc.org/articles/PMC7998292Test

3

Fatal Attraction: The Case of Toxic Soluble Dimers of Truncated PQBP-1 Mutants in X-Linked Intellectual Disability

المؤلفون: Yu Wai Chen, Shah Kamranur Rahman

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 2240, p 2240 (2021)

مصطلحات موضوعية: 0301 basic medicine, X-linked intellectual disability, Protein Conformation, Mutant, IDP, Review, Protein aggregation, Oligomer, lcsh:Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Genes, X-Linked, Frameshift Mutation, lcsh:QH301-705.5, Spectroscopy, biology, Chemistry, aggregation, General Medicine, Renpenning syndrome, Computer Science Applications, DNA-Binding Proteins, Biochemistry, RNA splicing, RNA Splicing, Intrinsically disordered proteins, Catalysis, Inorganic Chemistry, WW domain, 03 medical and health sciences, oligomerisation, Intellectual Disability, medicine, Humans, Physical and Theoretical Chemistry, Molecular Biology, XLID, Organic Chemistry, medicine.disease, intrinsically disordered protein, misfolding, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, biology.protein, dimerisation, Mutant Proteins, Fatal attraction, Protein Multimerization, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef1e3306de9bc1fae772f48bd3c359aTest
http://europepmc.org/articles/PMC7956452Test

4

ZFP36L2 Role in Thyroid Functionality

المؤلفون: Francesco Albano, Marco Colella, Concetta Ambrosino, Valeria Tucci, Luca Roberto, Filomena Russo, Immacolata Porreca, Mario De Felice, Massimo Mallardo, Pina Marotta, Perry J. Blackshear, Carla Reale

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9379, p 9379 (2021)
Volume 22
Issue 17

مصطلحات موضوعية: endocrine system diseases, Thyroid Gland, Thyrotropin, Notch1, 0302 clinical medicine, Gene expression, Transcriptional regulation, Biology (General), Receptor, Notch1, Spectroscopy, Regulation of gene expression, 0303 health sciences, Triiodothyronine, Thyroid, apoptosis, General Medicine, Computer Science Applications, Chemistry, medicine.anatomical_structure, Female, medicine.medical_specialty, endocrine system, Zfp36l2 KO, QH301-705.5, Cell Survival, 030209 endocrinology & metabolism, Biology, Catalysis, Article, Cell Line, Inorganic Chemistry, 03 medical and health sciences, PAX8 Transcription Factor, Tristetraprolin, In vivo, Internal medicine, medicine, Nis, Animals, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, 030304 developmental biology, Organic Chemistry, RNA stability, Mice, Mutant Strains, Rats, Mice, Inbred C57BL, Endocrinology, Gene Expression Regulation, hypothyroidism, PAX8, Gene Deletion, Hormone

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00254b463295726a2b636e9ac2a31fe3Test
http://europepmc.org/articles/PMC8431063Test

5

Role of Conserved Residues and F322 in the Extracellular Vestibule of the Rat P2X7 Receptor in Its Expression, Function and Dye Uptake Ability

المؤلفون: Audrey Mokdad, Marian Rupert, Anirban Bhattacharya, Hana Zemkova, Marie Jindrichova, Vendula Tvrdonova Stillerova, Eric Boué-Grabot

المساهمون: CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 8446, p 8446 (2020)
International Journal of Molecular Sciences, MDPI, 2020, 21 (22), pp.8446. ⟨10.3390/ijms21228446⟩
Volume 21
Issue 22

مصطلحات موضوعية: Models, Molecular, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Mutant, Gating, HEK293T cells, lcsh:Chemistry, 0302 clinical medicine, extracellular vestibule, Receptor, lcsh:QH301-705.5, Spectroscopy, Conserved Sequence, Alanine, 0303 health sciences, Chemistry, General Medicine, Computer Science Applications, Transmembrane domain, dye uptake, P2X7 receptor, gating, Ion Channel Gating, mutagenesis, Recombinant Fusion Proteins, Static Electricity, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Bacterial Proteins, Protein Domains, Extracellular, Animals, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Physical and Theoretical Chemistry, Molecular Biology, 030304 developmental biology, Organic Chemistry, Mutagenesis, HEK 293 cells, Rats, Kinetics, Luminescent Proteins, HEK293 Cells, lcsh:Biology (General), lcsh:QD1-999, Amino Acid Substitution, Biophysics, Mutagenesis, Site-Directed, Mutant Proteins, Receptors, Purinergic P2X7, deactivation, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26694e4269c0e0095685dc947288cbb0Test
http://europepmc.org/articles/PMC7696158Test

6

The Salt Sensitivity Induced by Disruption of Cell Wall-Associated Kinase 1 (SlWAK1) Tomato Gene Is Linked to Altered Osmotic and Metabolic Homeostasis

المؤلفون: Francisco B. Flores, Maria C. Bolarin, Fernando J. Yuste-Lisbona, Elisabeth Esch, Isabel Egea, Stéphanie Drevensek, Victoriano Meco, Fredy Barneche, Rafael Lozano, Ana Ortíz-Atienza, Wim H. Vriezen

المساهمون: Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centro de Investigación en Biotecnología Agroalimentaria, Universidad de Almería (UAL), Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, 21 (17), pp.6308. ⟨10.3390/IJMS21176308⟩
riUAL. Repositorio Institucional de la Universidad de Almería
Universidad de Almería
Volume 21
Issue 17
International Journal of Molecular Sciences, Vol 21, Iss 6308, p 6308 (2020)

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Osmosis, [SDV]Life Sciences [q-bio], Mutant, 01 natural sciences, Salt Stress, lcsh:Chemistry, Solanum lycopersicum, Cell Wall, Gene Expression Regulation, Plant, Homeostasis, lcsh:QH301-705.5, Spectroscopy, metabolites, Plant Proteins, 2. Zero hunger, Chlorosis, biology, Chemistry, food and beverages, General Medicine, Salt Tolerance, Sucrose transport, Computer Science Applications, Cell biology, ion stress, Osmotic shock, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, insertional mutant, Physical and Theoretical Chemistry, Molecular Biology, Abiotic stress, Organic Chemistry, fungi, Wild type, Biotic stress, biology.organism_classification, fruit yield, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, osmotic stress, Solanum, 010606 plant biology & botany, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019f60e9ce03c1ba061035194ab88121Test
http://hdl.handle.net/10835/8416Test

7

Cross-Recognition of Promoters by the Nine SigB Homologues Present in Streptomyces coelicolor A3(2)

المؤلفون: Bronislava Rezuchova, Jan Kormanec, Dagmar Homerova, Vladimira Mazurakova, Renata Novakova, Beatrica Sevcikova, Lubomira Feckova

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7849, p 7849 (2021)
Volume 22
Issue 15

مصطلحات موضوعية: Osmotic shock, Transcription, Genetic, QH301-705.5, Operon, Mutant, Sigma Factor, Streptomyces coelicolor, Bacillus subtilis, Biology, Streptomyces, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Bacterial Proteins, Sigma factor, Biology (General), Physical and Theoretical Chemistry, Promoter Regions, Genetic, QD1-999, Molecular Biology, Spectroscopy, 030304 developmental biology, Genetics, 0303 health sciences, promoter, Base Sequence, 030306 microbiology, Organic Chemistry, fungi, Promoter, regulation, General Medicine, differentiation, stress response, Gene Expression Regulation, Bacterial, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Computer Science Applications, Chemistry, bacteria

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303569918e82d0cf0b00a2e52db8f6f1Test
http://europepmc.org/articles/PMC8346170Test

8

Interaction of Pestiviral E1 and E2 Sequences in Dimer Formation and Intracellular Retention

المؤلفون: Yu Mu, Christine Luttermann, Birke Andrea Tews, Gregor Meyers

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7285, p 7285 (2021)
Volume 22
Issue 14

مصطلحات موضوعية: 0301 basic medicine, QH301-705.5, Intracellular localization, Dimer, 030106 microbiology, Cell, Mutant, RNA virus envelope protein, Clone (cell biology), Intracellular retention, Catalysis, Article, Cell Line, Inorganic Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Viral Envelope Proteins, Cricetinae, medicine, envelope protein heterodimer, Animals, Physical and Theoretical Chemistry, Biology (General), Molecular Biology, QD1-999, Spectroscopy, pestivirus, intracellular localization, biology, Organic Chemistry, Pestivirus, General Medicine, Virus Internalization, biology.organism_classification, Computer Science Applications, Cell biology, Chemistry, 030104 developmental biology, medicine.anatomical_structure, chemistry, Covalent bond, Mutation, Cattle, Rabbits, intracellular retention, Dimerization, envelope protein homooligomer

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd02de38ad73d98daedf88c562c8d41Test
http://europepmc.org/articles/PMC8306095Test

9

The Structural Effect of FLT3 Mutations at 835th Position and Their Interaction with Acute Myeloid Leukemia Inhibitors: In Silico Approach

المؤلفون: Abeer M. Al-Subaie, Balu Kamaraj

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7602, p 7602 (2021)
Volume 22
Issue 14

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Mutant, Gene mutation, medicine.disease_cause, fluids and secretions, 0302 clinical medicine, AML, hemic and lymphatic diseases, inhibitors, Biology (General), FLT3, Spectroscopy, Mutation, Chemistry, leukemia, Myeloid leukemia, hemic and immune systems, General Medicine, Computer Science Applications, Molecular Docking Simulation, Leukemia, flexibility, Leukemia, Myeloid, Acute, 030220 oncology & carcinogenesis, Flt3 mutation, embryonic structures, Molecular mechanism, QH301-705.5, In silico, interaction, Molecular Dynamics Simulation, Polymorphism, Single Nucleotide, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, medicine, Humans, Point Mutation, Computer Simulation, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, Protein Kinase Inhibitors, Organic Chemistry, medicine.disease, mutations, 030104 developmental biology, fms-Like Tyrosine Kinase 3, Drug Resistance, Neoplasm, Cancer research

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d45f84f690c9bf3d43b79af5ad669cTest
http://europepmc.org/articles/PMC8303888Test

10

Arabidopsis G-Protein β Subunit AGB1 Negatively Regulates DNA Binding of MYB62, a Suppressor in the Gibberellin Pathway

المؤلفون: Zhang He, Jun Chen, Weiya Xu, You-Zhi Ma, Xin Qi, Yong-Bin Zhou, Zhijin Fan, Tang Wensi, Ming Chen, Shiqin Gao, Chunxiao Wang, Zhao-Shi Xu, Li Weiwei

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 8270, p 8270 (2021)
Volume 22
Issue 15

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00b042541bd3ebb911e5669c7ecfcd1Test
http://europepmc.org/articles/PMC8347620Test

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