A new ergosterol analog, a new bis-anthraquinone and anti-obesity activity of anthraquinones from the marine sponge-associated fungus Talaromyces stipitatus KUFA 0207
| العنوان: | A new ergosterol analog, a new bis-anthraquinone and anti-obesity activity of anthraquinones from the marine sponge-associated fungus Talaromyces stipitatus KUFA 0207 |
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| المؤلفون: | Luís Gales, Michael Lee, José Alberto Pereira, Vitor Vasconcelos, Anake Kijjoa, Suradet Buttachon, Madalena Pinto, Ralph Urbatzka, Artur M. S. Silva, Tida Dethoup, Sara Freitas, Jidapa Noinart |
| المساهمون: | CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental |
| المصدر: | Marine Drugs; Volume 15; Issue 5; Pages: 139 Marine Drugs Marine Drugs, Vol 15, Iss 5, p 139 (2017) Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| بيانات النشر: | MDPI, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Models, Molecular, Aquatic Organisms, obesity, anti-obesity, Talaromyces, Ethyl acetate, Pharmaceutical Science, Anthraquinones, resveratrol, 01 natural sciences, emodin, Palmitic acid, chemistry.chemical_compound, citreorosein, Stylissa flabelliformis, Ergosterol, bis-anthraquinone, Drug Discovery, zebra fish, palmitic acid, lcsh:QH301-705.5, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Trichocomaceae, Citreorosein, ergosterol 5,8 endoperoxide, Molecular Structure, biology, sterol derivative, adult, stereochemistry, Porifera, unclassified drug, ergosta 4,6,8(14),22 tetraen 3 one, Secalonic acid, anthraquinone derivative, rheoemodin, crystal structure, questinol, Stereochemistry, animal experiment, embryo, talarosterone, Article, ergosterol derivatives, zebrafish Nile red assay, Animals, cyathisterone, controlled study, Talaromyces stipitatus, anthraquinones, secalonic acid A, 14. Life underwater, fallacinol, nonhuman, 010405 organic chemistry, X ray crystallography, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, drug structure, lcsh:Biology (General), chemistry, sponge (Porifera), Anti-Obesity Agents, Emodin |
| الوصف: | A new ergosterol analog, talarosterone (1) and a new bis-anthraquinone derivative (3) were isolated, together with ten known compounds including palmitic acid, ergosta-4,6,8(14),22- tetraen-3-one, ergosterol-5,8-endoperoxide, cyathisterone (2), emodin (4a), questinol (4b), citreorosein (4c), fallacinol (4d), rheoemodin (4e) and secalonic acid A (5), from the ethyl acetate extract of the culture of the marine sponge-associated fungus Talaromyces stipitatus KUFA 0207. The structures of the new compounds were established based on extensive 1D and 2D spectral analysis, and in the case of talarosterone (1), the absolute configurations of its stereogenic carbons were determined by X-ray crystallographic analysis. The structure and stereochemistry of cyathisterone (2) was also confirmed by X-ray analysis. The anthraquinones 4a-e and secalonic acid A (5) were tested for their anti-obesity activity using the zebrafish Nile red assay. Only citreorosein (4c) and questinol (4b) exhibited significant anti-obesity activity, while emodin (4a) and secalonic acid A (5) caused toxicity (death) for all exposed zebrafish larvae after 24 h. © 2017 by the authors. Licensee MDPI. This work was partially supported through national funds provided by the FCT-Foundation for Science and Technology and European Regional Development Fund (ERDF) and COMPETE, under the projects PEst-C/MAR/LA0015/2013, PTDC/MAR-BIO/4694/2014, as well as by the project INNOVMAR - Innovation and Sustainability in the Management and Exploitation of Marine Resources (reference NORTE-01-0145-FEDER-000035, within Research Line NOVELMAR/INSEAFOOD /ECOSERVICES), supported by the North Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). J. Noitnart thanks the ALFABET project under the ERASMUS MUNDUS ACTION 2 with South East Asia, for a scholarship. We thank J?lia Bessa and Sara Cravo for technical support. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5b26ab07a4f20037d1553b439156deTest https://hdl.handle.net/10216/120500Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6b5b26ab07a4f20037d1553b439156de |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |