دورية أكاديمية
Efficacy of Ketamine with and without Lamotrigine in Treatment-Resistant Depression: A Preliminary Report
| العنوان: | Efficacy of Ketamine with and without Lamotrigine in Treatment-Resistant Depression: A Preliminary Report |
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| المؤلفون: | Boney Joseph, Nicolas A. Nunez, Simon Kung, Jennifer L. Vande Voort, Vanessa K. Pazdernik, Kathryn M. Schak, Stacey M. Boehm, Brooke Carpenter, Emily K. Johnson, Grigoriy Malyshev, Nathan Smits, Daniel O. Adewunmi, Sarah K. Brown, Balwinder Singh |
| المصدر: | Pharmaceuticals, Vol 16, Iss 1164, p 1164 (2023) |
| بيانات النشر: | MDPI AG Multidisciplinary Digital Publishing Institute MDPI |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | lamotrigine, ketamine, esketamine, treatment-resistant depression, Medicine, Pharmacy and materia medica, RS1-441, psy, socio |
| الوصف: | Intravenous (IV) ketamine and FDA-approved intranasal (IN) esketamine are increasingly used for treatment-resistant depression (TRD). Preliminary studies have suggested a synergistic effect of ketamine and lamotrigine, although the data are inconclusive. Herein, we report the response to serial ketamine/esketamine treatment among patients with TRD with or without lamotrigine therapy. In this historical cohort study, we included adult patients with TRD who received serial IV racemic ketamine (0.5 mg/kg over 40−100 min) or IN esketamine (56/84 mg) treatments. A change in depressive symptoms was assessed using the 16-item Quick Inventory of Depressive Symptomatology self-report (QIDS-SR) scale. There were no significant differences in response or remission rates among the patients on or not on lamotrigine during the ketamine/esketamine treatments. For a percent change in the QIDS-SR from baseline, no interaction was found between the lamotrigine groups and treatment number ( p = 0.70), nor the overall effect of the group ( p = 0.38). There was a trend towards lower dissociation (based on the CADSS score) among current lamotrigine users, especially in patients who received IV ketamine. A major limitation is the limited number of patients taking lamotrigine (n = 13). This preliminary study provides insufficient evidence that continuing lamotrigine therapy attenuates the antidepressant effect of repeated ketamine/esketamine; however, there seems to be a signal toward attenuating dissociation with lamotrigine in patients receiving serial ketamine treatments. Further observational studies or randomized controlled trials are needed to replicate these findings. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.3390/ph16081164Test |
| DOI: | 10.3390/ph16081164 |
| الإتاحة: | https://doi.org/10.3390/ph16081164Test |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.16D42506 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ph16081164 |
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