دورية أكاديمية
Sex-Related Predisposition to Post-Traumatic Stress Disorder Development—The Role of Neuropeptides
| العنوان: | Sex-Related Predisposition to Post-Traumatic Stress Disorder Development—The Role of Neuropeptides |
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| المؤلفون: | Małgorzata Lehner, Anna Skórzewska, Aleksandra Wisłowska-Stanek |
| المصدر: | International Journal of Environmental Research and Public Health, Vol 19, Iss 314, p 314 (2021) |
| بيانات النشر: | MDPI AG MDPI Multidisciplinary Digital Publishing Institute |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | PTSD, sex differences, CRF, orexin, oxytocin, neuropeptide Y, Medicine, psy, scipo |
| الوصف: | Post-traumatic stress disorder (PTSD) is characterized by re-experiencing a traumatic event, avoidance, negative alterations in cognitions and mood, hyperarousal, and severe functional impairment. Women have a two times higher risk of developing PTSD than men. The neurobiological basis for the sex-specific predisposition to PTSD might be related to differences in the functions of stress-responsive systems due to the interaction between gonadal hormones and stress peptides such as corticotropin-releasing factor (CRF), orexin, oxytocin, and neuropeptide Y. Additionally, in phases where estrogens levels are low, the risk of developing or exacerbating PTSD is higher. Most studies have revealed several essential sex differences in CRF function. They include genetic factors, e.g., the CRF promoter contains estrogen response elements. Importantly, sex-related differences are responsible for different predispositions to PTSD and diverse treatment responses. Fear extinction (the process responsible for the effectiveness of behavioral therapy for PTSD) in women during periods of high endogenous estradiol levels (the primary form of estrogens) is reportedly more effective than in periods of low endogenous estradiol. In this review, we present the roles of selected neuropeptides in the sex-related predisposition to PTSD development. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.3390/ijerph19010314Test |
| DOI: | 10.3390/ijerph19010314 |
| الإتاحة: | https://doi.org/10.3390/ijerph19010314Test |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.EEFC4FD6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijerph19010314 |
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