Detection of Endotoxin in the Blood of Patients with Sepsis Due to Gram-Negative Bacteria
| العنوان: | Detection of Endotoxin in the Blood of Patients with Sepsis Due to Gram-Negative Bacteria |
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| المؤلفون: | T. E. Poore, R. S. Oser, Jack Levin, N. P. Zauber |
| المصدر: | New England Journal of Medicine. 283:1313-1316 |
| بيانات النشر: | Massachusetts Medical Society, 1970. |
| سنة النشر: | 1970 |
| مصطلحات موضوعية: | Gram-negative bacteria, medicine.drug_class, Antibiotics, Pneumococcal Infections, Microbiology, Sepsis, Crustacea, Methods, Humans, Medicine, biology, business.industry, Pneumonia, General Medicine, bacterial infections and mycoses, biology.organism_classification, medicine.disease, Endotoxins, Pneumococcal infections, Bacteremia, Limulus, Pneumococcal pneumonia, Immunology, Gelatin, business |
| الوصف: | A test for endotoxin was performed on the blood of 98 patients in whom septicemia due to gram-negative bacteria was suspected. The method was derived from a previous observation that endotoxin causes gelation of lysates of Limulus polyphemus amebocytes in vitro. Seventeen per cent of the patients studied had endotoxemia, as defined by this test. There was a good correlation between positive tests for endotoxin and bacteremia due to gram-negative organisms. Patients with pneumococcal pneumonia and bacteremia due to gram-positive organisms had negative tests. Endotoxin or endotoxin-like material was detected in the blood in concentrations from approximately 0.005 to 0.0005 μg per milliliter. Our data indicate that the limulus test is a sensitive, reliable and practical method for the detection of endotoxemia. |
| تدمد: | 1533-4406 0028-4793 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0e9ad0f4752043342a51e323e23d54Test https://doi.org/10.1056/nejm197012102832404Test |
| رقم الانضمام: | edsair.doi.dedup.....7b0e9ad0f4752043342a51e323e23d54 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15334406 00284793 |
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