المؤلفون: Loftus, Edward V Jr, Panés, Julian, Lacerda, Ana P, Peyrin-Biroulet, Laurent, D'Haens, Geert, Panaccione, Remo, Reinisch, Walter, Louis, Edouard, Chen, Minhu, Nakase, Hiroshi, Begun, Jakob, Boland, Brigid S, Phillips, Charles, Mohamed, Mohamed-Eslam F, Liu, Jianzhong, Geng, Ziqian, Feng, Tian, Dubcenco, Elena, Colombel, Jean-Frederic

المصدر: New England Journal of Medicine, 388 (21), 1966-1980 (2023-05-25)

مصطلحات موضوعية: Heterocyclic Compounds, 3-Ring, Janus Kinase Inhibitors, 4RA0KN46E0 (upadacitinib), Humans, Crohn Disease/complications/drug therapy, Herpes Zoster/chemically induced/etiology, 3-Ring/administration & dosage/adverse effects/therapeutic use, Janus Kinase Inhibitors/administration & dosage/adverse effects/therapeutic use, Neutropenia/chemically induced/etiology, Induction Chemotherapy/adverse effects/methods, Maintenance Chemotherapy/adverse effects/methods, Human health sciences, Gastroenterology & hepatology, Sciences de la santé humaine, Gastroentérologie & hépatologie

العلاقة: urn:issn:0028-4793; urn:issn:1533-4406; https://orbi.uliege.be/handle/2268/304716Test; info:hdl:2268/304716; https://orbi.uliege.be/bitstream/2268/304716/1/UPA%20CD%20primary%20published%205.24.23.pdfTest; scopus-id:2-s2.0-85160165903; info:pmid:37224198

الإتاحة: https://doi.org/10.1056/NEJMoa2212728Test
https://orbi.uliege.be/handle/2268/304716Test
https://orbi.uliege.be/bitstream/2268/304716/1/UPA%20CD%20primary%20published%205.24.23.pdfTest

المؤلفون: Joseph F. Merola, Jaclyn K Anderson, Marina Magrey, Liang Chen, P. Zueger, César Pacheco-Tena, J. Liu, Iain B. McInnes, X. Wang, Mitsumasa Kishimoto, Yi Liu, Frank Behrens, Aileen L. Pangan, Slawomir Jeka

المساهمون: Publica

المصدر: New England Journal of Medicine. 384:1227-1239

مصطلحات موضوعية: Adult, Male, musculoskeletal diseases, Oncology, medicine.medical_specialty, Arthritis, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, Internal medicine, medicine, Adalimumab, Humans, Janus Kinase Inhibitors, 030212 general & internal medicine, Least-Squares Analysis, skin and connective tissue diseases, Janus kinase inhibitor, Dose-Response Relationship, Drug, business.industry, Liver Diseases, Arthritis, Psoriatic, General Medicine, Middle Aged, medicine.disease, Clinical trial, Multicenter study, Antirheumatic Agents, Female, Tumor necrosis factor alpha, business, Heterocyclic Compounds, 3-Ring, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4bf0d488be87dd806fa5b98002f4feTest
https://doi.org/10.1056/nejmoa2022516Test

المؤلفون: Majed Alabdulhafid, Zobaida Alsum, Fahad A. Bashiri, Abdullah A. Alangari, Jacinta Bustamante, Emmanuelle Jouanguy, Rabih Halwani, Malak Alghamdi, Hamdy H. Hassan, Dusan Bogunovic, Areej Rashid Alkahtani, Fahad Alsohime, Najla Alotaibi, Nouf Alkhamis, Mohamad-Hani Temsah, Marta Martín-Fernández, Conor Gruber, Ayman Al-Eyadhy, Saleh Al-Muhsen, Xueer Qiu, Gamal M Hasan, Tom Le Voyer, Sofija Buta, Jean-Laurent Casanova

المصدر: N Engl J Med

مصطلحات موضوعية: Male, Ruxolitinib, Inflammation, 030204 cardiovascular system & hematology, medicine.disease_cause, Systemic inflammation, Article, 03 medical and health sciences, 0302 clinical medicine, Loss of Function Mutation, Interferon, Nitriles, Exome Sequencing, medicine, Humans, Janus Kinase Inhibitors, 030212 general & internal medicine, Exome sequencing, Receptors, Interferon, Mutation, Kinase, business.industry, Interleukins, Hereditary Autoinflammatory Diseases, Homozygote, Remission Induction, Infant, Newborn, Janus Kinase 1, General Medicine, Shock, Septic, Pyrimidines, Respiratory failure, Immunology, Pyrazoles, Interferons, medicine.symptom, business, Ubiquitin Thiolesterase, Hydrocephalus, Signal Transduction, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a6716ffb29998917844b19d39aa45bTest
https://doi.org/10.1056/nejmoa1905633Test

المؤلفون: Kalil, Andre C, Patterson, Thomas F, Mehta, Aneesh K, Tomashek, Kay M, Wolfe, Cameron R, Ghazaryan, Varduhi, Marconi, Vincent C, Ruiz-Palacios, Guillermo M, Hsieh, Lanny, Kline, Susan, Tapson, Victor, Iovine, Nicole M, Jain, Mamta K, Sweeney, Daniel A, El Sahly, Hana M, Branche, Angela R, Regalado Pineda, Justino, Lye, David C, Sandkovsky, Uriel, Luetkemeyer, Anne F, Cohen, Stuart H, Finberg, Robert W, Jackson, Patrick EH, Taiwo, Babafemi, Paules, Catharine I, Arguinchona, Henry, Erdmann, Nathaniel, Ahuja, Neera, Frank, Maria, Oh, Myoung-Don, Kim, Eu-Suk, Tan, Seow Y, Mularski, Richard A, Nielsen, Henrik, Ponce, Philip O, Taylor, Barbara S, Larson, LuAnn, Rouphael, Nadine G, Saklawi, Youssef, Cantos, Valeria D, Ko, Emily R, Engemann, John J, Amin, Alpesh N, Watanabe, Miki, Billings, Joanne, Elie, Marie-Carmelle, Davey, Richard T, Burgess, Timothy H, Ferreira, Jennifer, Green, Michelle, Makowski, Mat, Cardoso, Anabela, de Bono, Stephanie, Bonnett, Tyler, Proschan, Michael, Deye, Gregory A, Dempsey, Walla, Nayak, Seema U, Dodd, Lori E, Beigel, John H, ACTT-2 Study Group Members

المصدر: The New England Journal of Medicine
New England Journal of Medicine
The New England journal of medicine, vol 384, iss 9
Kalil, A C, Patterson, T F, Mehta, A K, Tomashek, K M, Wolfe, C R, Ghazaryan, V, Marconi, V C, Ruiz-palacios, G M, Hsieh, L, Kline, S, Tapson, V, Iovine, N M, Jain, M K, Sweeney, D A, El Sahly, H M, Branche, A R, Regalado Pineda, J, Lye, D C, Sandkovsky, U, Luetkemeyer, A F, Cohen, S H, Finberg, R W, Jackson, P E H, Taiwo, B, Paules, C I, Arguinchona, H, Erdmann, N, Ahuja, N, Frank, M, Oh, M, Kim, E, Tan, S Y, Mularski, R A, Nielsen, H, Ponce, P O, Taylor, B S, Larson, L, Rouphael, N G, Saklawi, Y, Cantos, V D, Ko, E R, Engemann, J J, Amin, A N, Watanabe, M, Billings, J, Elie, M, Davey, R T, Burgess, T H, Ferreira, J, Green, M & ACTT-2 Study Group 2021, ' Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 ', New England Journal of Medicine, vol. 384, no. 9, pp. 795-807 . https://doi.org/10.1056/NEJMoa2031994Test
Kalil, A C, Patterson, T F, Mehta, A K, Tomashek, K M, Wolfe, C R, Ghazaryan, V, Marconi, V C, Ruiz-Palacios, G M, Hsieh, L, Kline, S, Tapson, V, Iovine, N M, Jain, M K, Sweeney, D A, El Sahly, H M, Branche, A R, Regalado Pineda, J, Lye, D C, Sandkovsky, U, Luetkemeyer, A F, Cohen, S H, Finberg, R W, Jackson, P E H, Taiwo, B, Paules, C I, Arguinchona, H, Goepfert, P, Ahuja, N, Frank, M, Oh, M, Kim, E S, Tan, S Y, Mularski, R A, Nielsen, H, Ponce, P O, Taylor, B S, Larson, L, Rouphael, N G, Saklawi, Y, Cantos, V D, Ko, E R, Engemann, J J, Amin, A N, Watanabe, M, Billings, J, Elie, M-C, Davey, R T, Burgess, T H, Ferreira, J, Green, M & ACTT-2 Study Group Members 2021, ' Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 ', New England Journal of Medicine, vol. 384, no. 9, pp. 795-807 . https://doi.org/10.1056/NEJMoa2031994Test

مصطلحات موضوعية: Male, 030204 cardiovascular system & hematology, Rate ratio, Medical and Health Sciences, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Hospital Mortality, 030212 general & internal medicine, Lung, Sulfonamides, Alanine, Respiration, Rehabilitation, Hazard ratio, General Medicine, Middle Aged, Hospitalization, Editorial, Treatment Outcome, 6.1 Pharmaceuticals, Combination, Artificial, Drug Therapy, Combination, Female, Original Article, Adult, medicine.medical_specialty, Randomization, Clinical Trials and Supportive Activities, Placebo, Antiviral Agents, 03 medical and health sciences, Drug Therapy, Double-Blind Method, Clinical Research, General & Internal Medicine, Internal medicine, medicine, ACTT-2 Study Group Members, Janus Kinase Inhibitors, Humans, Adverse effect, Aged, SARS-CoV-2, business.industry, Oxygen Inhalation Therapy, COVID-19, Evaluation of treatments and therapeutic interventions, Odds ratio, Respiration, Artificial, Adenosine Monophosphate, Confidence interval, COVID-19 Drug Treatment, Good Health and Well Being, Purines, Azetidines, Pyrazoles, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20f069b053b3a62c791901b611263cdTest
https://doi.org/10.1056/nejmoa2031994Test

المؤلفون: Volker M. Lauschke, Justin Stebbing

المساهمون: National Institute for Health Research, Imperial College Healthcare NHS Trust- BRC Funding

المصدر: New England Journal of Medicine
The New England Journal of Medicine

مصطلحات موضوعية: 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), macromolecular substances, 030204 cardiovascular system & hematology, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, General & Internal Medicine, medicine, Humans, Janus Kinase Inhibitors, 030212 general & internal medicine, Glucocorticoids, 11 Medical and Health Sciences, business.industry, musculoskeletal, neural, and ocular physiology, virus diseases, General Medicine, Virology, 3. Good health, Editorial, nervous system, Original Article, medicine.symptom, business, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72eec3ac622aa68806d376d97ac263baTest
https://doi.org/10.1056/nejme2108667Test

المؤلفون: Maureen Rischmueller, Naomi Martin, N. Khan, Aileen L. Pangan, Ying Zhang, Jeffrey Enejosa, Boulos Haraoui, Ricardo Machado Xavier, A. Rubbert-Roth

المصدر: New England Journal of Medicine. 383:1511-1521

مصطلحات موضوعية: musculoskeletal diseases, Oncology, medicine.medical_specialty, Intention-to-treat analysis, business.industry, Abatacept, Arthritis, General Medicine, 030204 cardiovascular system & hematology, medicine.disease, law.invention, Clinical trial, 03 medical and health sciences, 0302 clinical medicine, Multicenter study, Randomized controlled trial, law, Rheumatoid arthritis, Internal medicine, medicine, 030212 general & internal medicine, business, medicine.drug, Janus kinase inhibitor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6a88f7e563ec893b19141dda28d6f831Test
https://doi.org/10.1056/nejmoa2008250Test

المؤلفون: Nicole Ulrick, Abigail Collins, Sabrina W. Yum, Thais Armangue, Justine Shults, Katherine L. Boyle, Katherine McDonald, Francesco Gavazzi, Asako Takanohashi, Holly Dubbs, Amy Pizzino, Constance Besnier, Omar Sherbini, Carly Scher, Kyle Peer, Stephanie Keller, Pierre Lebon, Sarah Woidill, Nicole Jaffe, Jullie Rhee, Julia Kramer-Golinkoff, Guy Helman, David B. Frank, Adeline Vanderver, Jamie Koh, Jean-François Meritet, Laura Adang

المصدر: N Engl J Med

مصطلحات موضوعية: Extramural, business.industry, Central nervous system, General Medicine, 030204 cardiovascular system & hematology, medicine.disease, Article, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine.anatomical_structure, medicine, Cancer research, Aicardi–Goutières syndrome, 030212 general & internal medicine, business, Janus kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd90a8dd50648581e3f80225ed33894Test
https://doi.org/10.1056/nejmc2001362Test

المؤلفون: Iain B. McInnes, Georg Schett, Markus F. Neurath

مصطلحات موضوعية: Inflammation, business.industry, medicine.medical_treatment, Interleukins, Arthritis, Psoriatic, Arthritis, General Medicine, medicine.disease, Inflammatory Bowel Diseases, Autoimmune Diseases, Arthritis, Rheumatoid, Cytokine, Immune System Diseases, Immunology, Spondylarthritis, medicine, Cytokines, Humans, Janus Kinase Inhibitors, Immune-mediated inflammatory diseases, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496dcc18db9eb9eeaf0678748d0bf6a2Test
https://eprints.gla.ac.uk/249994/1/249994.pdfTest

المؤلفون: Anjela Galan, William Damsky, Nkiruka Emeagwali, Brett A. King, Durga Thakral

المصدر: New England Journal of Medicine. 379:2540-2546

مصطلحات موضوعية: medicine.medical_specialty, Sarcoidosis, Cutaneous Sarcoidosis, Disease, Skin Diseases, Article, Lesion, Pathogenesis, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Piperidines, Sarcoidosis, Pulmonary, medicine, Humans, Pyrroles, Protein Kinase Inhibitors, Janus Kinases, Skin, Tofacitinib, Sequence Analysis, RNA, business.industry, Remission Induction, General Medicine, Middle Aged, medicine.disease, Immunohistochemistry, Dermatology, STAT Transcription Factors, Pyrimidines, 030228 respiratory system, Female, medicine.symptom, business, Janus kinase, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11c2ad3e6050cd0c3aff38d6b0427bcTest
https://doi.org/10.1056/nejmoa1805958Test

المؤلفون: I. Peter Shintaku, Grace Cherry, Siwen Hu-Lieskovan, Davis Y. Torrejon, Salemiz Sandoval, Blanca Homet Moreno, Lucas Barthly, Jia Pang, Thomas G. Graeber, Gabriel Abril-Rodriguez, Antoni Ribas, Xiangju Kong, Roger S. Lo, Justin Saco, Jesse M. Zaretsky, Helena Escuin-Ordinas, Ton N. Schumacher, Begoña Comin-Anduix, Elizabeth Seja, Daniel Sanghoon Shin, Phillip J. Sanchez, Willy Hugo, Kathleen Ruchalski, Beata Berent-Maoz, Paul C. Tumeh, Riccardo Mezzadra, Cristina Puig-Saus, Angel Garcia-Diaz, Bartosz Chmielowski

المصدر: The New England journal of medicine, vol 375, iss 9
Zaretsky, JM; Garcia-Diaz, A; Shin, DS; Escuin-Ordinas, H; Hugo, W; Hu-Lieskovan, S; et al.(2016). Mutations associated with acquired resistance to PD-1 blockade in melanoma. New England Journal of Medicine, 375(9), 819-829. doi: 10.1056/NEJMoa1604958. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4157s0msTest

مصطلحات موضوعية: 0301 basic medicine, Oncology, Biopsy, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Drug Resistance, Pembrolizumab, Drug resistance, Medical and Health Sciences, MHC Class I, 0302 clinical medicine, Recurrence, Monoclonal, 2.1 Biological and endogenous factors, Medicine, Exome, Melanoma, Humanized, Cancer, Janus kinase 2, biology, medicine.diagnostic_test, Janus kinase 1, General Medicine, 030220 oncology & carcinogenesis, Immunotherapy, Sequence Analysis, Signal Transduction, medicine.medical_specialty, Antineoplastic Agents, Context (language use), Antibodies, Interferon-gamma, 03 medical and health sciences, Rare Diseases, Clinical Research, General & Internal Medicine, Internal medicine, Genetics, Humans, Neoplastic, business.industry, Human Genome, DNA, Janus Kinase 1, Janus Kinase 2, medicine.disease, 030104 developmental biology, Genes, Gene Expression Regulation, Mutation, Immunology, biology.protein, Neoplasm, beta 2-Microglobulin, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8ea6dcb112ddb4bea490a1d98adc88Test
https://doi.org/10.1056/nejmoa1604958Test