Screening for Hemochromatosis
العنوان: | Screening for Hemochromatosis |
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المؤلفون: | Jane F. Desforges, Corwin Q. Edwards, James P. Kushner |
المصدر: | New England Journal of Medicine. 328:1616-1620 |
بيانات النشر: | Massachusetts Medical Society, 1993. |
سنة النشر: | 1993 |
مصطلحات موضوعية: | Adult, Male, Isoantigens, medicine.medical_specialty, Genetic Linkage, Daily intake, Absorption (skin), HLA-A3 Antigen, Intestinal mucosa, Blood loss, Internal medicine, Humans, Medicine, Alleles, Hemochromatosis, Dietary iron, business.industry, General Medicine, Sloughing, medicine.disease, Pedigree, Endocrinology, Hereditary hemochromatosis, Ferritins, business |
الوصف: | In the United States the average daily intake of dietary iron ranges from 10 to 30 mg, but only about 1 mg is absorbed, to balance precisely the loss due to the sloughing of intact cells containing iron. Iron absorption can be increased if iron stores are depleted (usually through blood loss), and in genetically normal people absorption decreases with iron overload1,2 (usually from multiple transfusions). Iron balance is regulated at the absorptive step, but the mechanism by which the intestinal mucosa accomplishes this has not been defined. The defect responsible for hereditary hemochromatosis is malregulation of intestinal iron . . . |
تدمد: | 1533-4406 0028-4793 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c779717199ff078ec0e562e13c34f684Test https://doi.org/10.1056/nejm199306033282208Test |
رقم الانضمام: | edsair.doi.dedup.....c779717199ff078ec0e562e13c34f684 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15334406 00284793 |
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