دورية أكاديمية
Recurrent pregnancy loss in women with Hashimoto's thyroiditis with concurrent non-endocrine autoimmune disorders
| العنوان: | Recurrent pregnancy loss in women with Hashimoto's thyroiditis with concurrent non-endocrine autoimmune disorders |
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| المؤلفون: | Miriam Cellini, Maria Giulia Santaguida, Ilaria Stramazzo, Silvia Capriello, Nunzia Brusca, Alessandro Antonelli, Poupak Fallahi, Lucilla Gargano, Marco Centanni, Camilla Virili |
| المساهمون: | Cellini, Miriam, Santaguida, MARIA GIULIA, Stramazzo, Ilaria, Capriello, Silvia, Brusca, Nunzia, Antonelli, Alessandro, Fallahi, Poupak, Gargano, Lucilla, Centanni, Marco, Virili, Camilla |
| بيانات النشر: | Mary Ann Liebert inc. New York, USA |
| سنة النشر: | 2020 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | Hashimoto's thyroiditi, hypothyroidism, miscarriage, poly-autoimmunity, recurrent pregnancy loss |
| الوصف: | Background: An increased rate of recurrent miscarriage has been described in patients with autoimmune thyroid disease. However, there is a lack of studies that assess the rate of recurrent pregnancy loss (RPL) in patients with Hashimoto's thyroiditis (HT) isolated or with concurrent non-endocrine autoimmune disorders (NEAD). The objective of the study was to assess the rate of RPL in patients with HT isolated or accompanied with non-endocrine autoimmune diseases. Methods: This is a retrospective observational cohort study with a systematic review of the NEAD with concurrent HT in an outpatient Endocrinology Unit at a University Hospital. Among the 3480 consecutively examined women with HT, 87 patients met the criteria of RPL and represented the study group. Sixty-five of them had isolated HT and 22 women had HT+NEAD. Results: The rate of RPL in women with HT was 2.1% versus 5.64% observed in women with HT+NEAD (odds ratio = 2.78 [95% confidence interval 1.70-4.57]; p < 0.0001). On subdivision, this difference was still evident in euthyroid patients (p < 0.0001), while it disappeared in hypothyroid women (p = 0.21). The RPL did not correlate with the autoantibody concentrations nor in women with isolated HT nor in those with HT+NEAD. The presence of antiphospholipid syndrome (APS) explained RPL in 3 out of 22 (14%) patients with HT+NEAD, the remaining being related to different autoimmune disorders. Interestingly, even subtracting the patients with APS, RPL was more frequent in patients with poly-autoimmunity than in patients with isolated HT (p = 0.0013). Conclusions: The co-presence of NEAD is correlated with a higher risk of RPL in women with HT. The association with APS may explain only a fraction of RPL rate in patients with poly-autoimmunity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31910128; info:eu-repo/semantics/altIdentifier/wos/WOS:000524895400016; volume:3; issue:30; firstpage:457; lastpage:462; numberofpages:6; journal:THYROID; http://hdl.handle.net/11573/1409469Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85081945011 |
| DOI: | 10.1089/thy.2019.0456 |
| الإتاحة: | https://doi.org/10.1089/thy.2019.0456Test http://hdl.handle.net/11573/1409469Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C9A7942 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1089/thy.2019.0456 |
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