دورية أكاديمية
Can the Prognosis of COVID-19 Disease Be Determined by Fecal Markers and Cytokines?
| العنوان: | Can the Prognosis of COVID-19 Disease Be Determined by Fecal Markers and Cytokines? |
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| المؤلفون: | Türkmen A.D., Ünlü G., Musayeva G., Akkuş E., Özen A.G., Önal P., Kuşkucu M. |
| بيانات النشر: | Mary Ann Liebert Inc. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | children, COVID-19 disease, fecal cytokines, fecal markers, alpha interferon, biological marker, calcium binding protein, cytokine, gamma interferon, hemoglobin, interleukin 10, interleukin 2, interleukin 4, interleukin 5, interstitial collagenase, leukocyte elastase, lysozyme, myeloperoxidase, protein S100B, peroxidase, Article, child, clinical article, cohort analysis, controlled study, coronavirus disease 2019, cross-sectional study, feces analysis, feces level, female |
| الوصف: | The coronavirus disease 2019 (COVID-19) pandemic has affected the entire world, and has a variety of clinical presentations. The aim of this study is to determine the relationships of fecal cytokines and markers with the symptoms and prognosis of children with COVID-19 infection, and to identify noninvasive markers during follow-up. In a cohort of 40 COVID-19-positive children and 40 healthy controls, fecal cytokines and markers were examined in stool samples. A binary logistic model was used to assess the potential of cytokines as risk factors for hospitalization. Odds ratios (ORs) with 95% confidence intervals (CIs) were reported. A P-value <0.05 was accepted as statistically significant. Levels of fecal lysozyme, myeloperoxidase, hemoglobin, and interleukin-5 (IL-5) (P < 0.05) were significantly higher among the patients than controls. In a logistic regression analysis, fecal IL-2 (OR = 3.83; 95% CI: 1.44-15.92), IL-4 (OR = 2.96; 95% CI: 1.09-12.93), IL-5 (OR = 4.56; 95% CI: 1.18-27.88), IL-10 (OR = 2.71 95% CI: 1.19-7.94), interferon-gamma (IFN-?) (OR = 4.03; 95% CI: 1.44-15.73), IFN-? (OR = 3.02; 95% CI: 1.08-11.65), calcium-binding protein B S100 (S100 B) (OR = 4.78; 95% CI: 1.31-27.82), neutrophil elastase (NE) 2 (OR = 4.07; 95% CI: 1.17-19.69), and matrix metalloproteinase 1 (MMP-1) (OR = 3.67; 95% CI: 1.1-18.82) levels were significantly higher in hospitalized patients with COVID-19 infection than outpatients. We demonstrated that various fecal cytokines and markers were increased in patients who had COVID-19. Fecal IL-2, IL-4, IL-5, IL-10, IFN-?, IFN-?, S100 B, NE, and MMP-1 levels were significantly elevated in hospitalized patients. We suggest that the fecal and serum levels of cytokines could be used to predict the prognosis of COVID-19 disease, although more studies are needed to confirm this. © 2022 Mary Ann Liebert, Inc. ; TSG-2020-34992 ; The authors thank Istanbul-Cerrahpasa University Scientific Research Projects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 10799907 |
| العلاقة: | Journal of Interferon and Cytokine Research; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1089/jir.2022.0098Test; https://hdl.handle.net/20.500.12831/12844Test; 42; 10; 542; 549; 2-s2.0-85140658828 |
| DOI: | 10.1089/jir.2022.0098 |
| الإتاحة: | https://doi.org/10.1089/jir.2022.0098Test https://doi.org/20.500.12831/12844Test https://hdl.handle.net/20.500.12831/12844Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.F2E0B438 |
| قاعدة البيانات: | BASE |
| تدمد: | 10799907 |
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| DOI: | 10.1089/jir.2022.0098 |