Role of Inflammasome Activation in the Pathophysiology of Vascular Diseases of the Neurovascular Unit
| العنوان: | Role of Inflammasome Activation in the Pathophysiology of Vascular Diseases of the Neurovascular Unit |
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| المؤلفون: | Tauheed Ishrat, Azza B. El-Remessy, Susan C. Fagan, Islam N. Mohamed |
| المصدر: | Antioxidants & Redox Signaling. 22:1188-1206 |
| بيانات النشر: | Mary Ann Liebert Inc, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Inflammasomes, Physiology, Clinical Biochemistry, Inflammation, Biology, Bioinformatics, Biochemistry, Retina, Immune system, medicine, Animals, Humans, Vascular Diseases, Receptor, Molecular Biology, General Environmental Science, Innate immune system, Mechanism (biology), Brain, Neurodegenerative Diseases, Inflammasome, Cell Biology, Forum Review Articles, Neurovascular bundle, Pathophysiology, Oxidative Stress, Central Serous Chorioretinopathy, Receptors, Pattern Recognition, Immunology, General Earth and Planetary Sciences, medicine.symptom, medicine.drug |
| الوصف: | Significance: Inflammation is the standard double-edged defense mechanism that aims at protecting the human physiological homeostasis from devastating threats. Both acute and chronic inflammation have been implicated in the occurrence and progression of vascular diseases. Interference with components of the immune system to improve patient outcome after ischemic injury has been uniformly unsuccessful. There is a need for a deeper understanding of the innate immune response to injury in order to modulate, rather than to block inflammation and improve the outcome for vascular diseases. Recent Advances: Nucleotide-binding oligomerization domain-like receptors or NOD-like receptor proteins (NLRPs) can be activated by sterile and microbial inflammation. NLR family plays a major role in activating the inflammasome. Critical Issues: The aim of this work is to review recent findings that provided insights into key inflammatory mechanisms and define the place of the inflammasome, a multi-protein complex involved in instigating inflammation in neurovascular diseases, including retinopathy, neurodegenerative diseases, and stroke. Future Directions: The significant contribution of NLRP-inflammasome activation to vascular disease of the neurovascular unit in the brain and retina suggests that therapeutic strategies focused on specific targeting of inflammasome components could significantly improve the outcomes of these diseases. Antioxid. Redox Signal. 22, 1188–1206. |
| تدمد: | 1557-7716 1523-0864 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f068802b93bfce849b21c2de72ce8609Test https://doi.org/10.1089/ars.2014.6126Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f068802b93bfce849b21c2de72ce8609 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577716 15230864 |
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